The interface of receptor trafficking and signalling.
The interface of receptor trafficking and signalling.
复制标题
受体运输和信号传导的界面。
DOI：
10.1037/0735-7044.116.4.588
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发表时间：
2001
影响因子：
4
通讯作者：
S. Urbé
中科院分区：
文献类型：
--
作者：
M. J. Clague;S. Urbé
受体运输和信号传导之间的密切关系开始揭示其秘密。受体内吞作用通过将受体转移到降解区室来提供信号传导衰减的机制。然而，它也可以通过提供与质膜相比不同的内吞隔室下游效应物组合来确定信号输出。Rab5、Hrs和Cbl是可以影响酪氨酸激酶受体运输和信号传导途径的蛋白质的三个实例。通过在这个交叉点上运作，它们很好地将细胞功能的这些方面结合起来。Rab5 GT3循环的每个元件都受到信号转导事件的影响，这将相应地影响效应蛋白的募集和受体分布。Hrs和Cbl都在生长因子刺激下发生酪氨酸磷酸化，被认为影响早期内体中的受体分选并参与多种相互作用，这可能在信号级联中起直接作用。
The intimate relationship between receptor trafficking and signalling is beginning to reveal its secrets. Receptor endocytosis provides a mechanism for attenuation of signalling by transfer of receptors to degradative compartments. However, it can also determine signalling output by providing a different combination of downstream effectors at endocytic compartments compared with the plasma membrane. Rab5, Hrs and Cbl, are three examples of proteins that can influence both tyrosine kinase receptor trafficking and signalling pathways. By operating at this intersection, they are well placed to couple these aspects of cell function. Each element of the Rab5 GTPase cycle is influenced by signal transduction events, which will correspondingly influence recruitment of effector proteins and receptor distribution. Hrs and Cbl, which both undergo tyrosine phosphorylation in response to growth factor stimulation, are believed to influence receptor sorting in the early endosome and engage in multiple interactions, which may play a direct role in signalling cascades.
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影响因子：
56.9
作者：
Luttrell, LM;Ferguson, SSG;Lefkowitz, RJ
通讯作者：
Lefkowitz, RJ
影响因子：
3.3
作者：
Burke, P;Schooler, K;Wiley, HS
通讯作者：
Wiley, HS
DOI：
10.1073/pnas.95.14.7927
发表时间：
1998-07-07
影响因子：
11.1
作者：
Miyake, S;Lupher, ML;Band, H
通讯作者：
Band, H
影响因子：
10.5
作者：
Levkowitz, G;Waterman, H;Yarden, Y
通讯作者：
Yarden, Y
影响因子：
16
作者：
Cavalli, V;Vilbois, F;Gruenberg, J
通讯作者：
Gruenberg, J