Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion.
Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion.
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垂直传播感染是妊娠期间胎儿发病率和死亡率的一个重要原因，并对胎儿发育构成重大风险。这些感染主要通过两条途径传播给胎儿：(1)直接侵入并穿过分隔母胎循环的胎盘，或(2)上升母体生殖道机智并进入子宫。通常只有两种细菌能穿过胎盘感染胎儿：单核细胞增多性李斯特菌和梅毒螺旋体亚种。梅毒。单核细胞增多性乳杆菌是一种革兰氏阳性的食源性病原体，发现于土壤中，可急性感染多种哺乳动物物种。梅毒螺旋体是一种性传播的螺旋体，只在人类中引起慢性感染。我们简要回顾了这两种非常不同的细菌成功地克服了胎盘屏障的发病机制，以及胎盘免疫在抵抗感染中所起的作用。这两种生物都有共同的特征，这有助于它们通过胎盘传播。这些问题包括在宿主内广泛传播的能力，逃避免疫吞噬作用，以及需要强大的T细胞反应来消除它们。
Vertically transmitted infections are a significant cause of fetal morbidity and mortality during pregnancy and pose substantial risks to fetal development. These infections are primarily transmitted to the fetus through two routes: (1) direct invasion and crossing the placenta which separates maternal and fetal circulation, or (2) ascending the maternal genitourinary tact and entering the uterus. Only two bacterial species are commonly found to cross the placenta and infect the fetus: Listeria monocytogenes and Treponema pallidum subsp. pallidum. L. monocytogenes is a Gram-positive, foodborne pathogen found in soil that acutely infects a wide variety of mammalian species. T. pallidum is a sexually transmitted spirochete that causes a chronic infection exclusively in humans. We briefly review the pathogenesis of these two very distinct bacteria that have managed to overcome the placental barrier and the role placental immunity plays in resisting infection. Both organisms share characteristics which contribute to their transplacental transmission. These include the ability to disseminate broadly within the host, evade immune phagocytosis, and the need for a strong T cell response for their elimination.
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影响因子：
24.1
作者：
Clark, Dayna R.;Chaturvedi, Vandana;Way, Sing Sing
通讯作者：
Way, Sing Sing
影响因子：
6.7
作者：
Rowe JH;Ertelt JM;Xin L;Way SS
通讯作者：
Way SS
影响因子：
56.3
作者：
Charlier, Caroline;Perrodeau, Elodie;Lecuit, Marc
通讯作者：
Lecuit, Marc
影响因子：
3.4
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
通讯作者：
Tilburgs T
影响因子：
6.4
作者：
Azari S;Johnson LJ;Webb A;Kozlowski SM;Zhang X;Rood K;Amer A;Seveau S
通讯作者：
Seveau S