Postprandial elevation of remnant lipoprotein leads to endothelial dysfunction.
Postprandial elevation of remnant lipoprotein leads to endothelial dysfunction.
复制标题
餐后残余脂蛋白升高导致内皮功能障碍。
DOI：
10.1253/circj.66.127
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Hiwada
中科院分区：
文献类型：
--
作者：
J. Funada;M. Sekiya;M. Hamada;K. Hiwada
最近的研究表明，在禁食状态下，残留物样颗粒（RLP-C）形式的胆固醇水平升高会导致内皮功能恶化，但尚不清楚餐后RLP-C升高是否具有相同的效果。本研究的目的是评估24名空腹正常血脂受试者餐后RLP-C升高对内皮功能的影响。研究了反应性充血时肱动脉血流介导的扩张（FMD）。测定空腹和常规脂肪负荷后4小时的血脂和脂蛋白。将受试者分为高反应组（餐后RLP-C水平>7.5mg/dl, n=8）和正常反应组（餐后RLP-C水平<或=7.5mg/dl, n=16）。在高应答者中观察到甘油三酯和RLP-C水平的显著增加。高反应组基础FMD（4.3+/-3.0%）显著低于正常反应组（8.3+/-2.4%）（p<0.01），但两组增脂后FMD无显著变化。脂肪负荷试验期间RLP-C水平的变化与基础FMD显著相关（r=-0.588, p<0.01）。多元回归分析显示，基础FMD与RLP-C水平变化呈显著相关（r=-0.488, p<0.02）。这项研究的结果表明，餐后RLP-C升高可能与动脉粥样硬化进展有关，即使在正常血脂的受试者中也是如此。
Recent studies have demonstrated that elevated levels of cholesterol in the form of remnant-like particles (RLP-C) induce deterioration of endothelial function during the fasting state, but it is not known whether postprandial RLP-C elevation has the same effect. The objective of this study was to assess the effect of postprandial RLP-C elevation on endothelial function in 24 fasting normolipidemic subjects. Flow-mediated dilatation (FMD) during reactive hyperemia in the brachial artery was investigated. Serum lipids and lipoproteins during fasting and 4h after regular fat-loading were measured. Subjects were divided into 2 groups: the high responders (postprandial RLP-C level >7.5mg/dl, n=8) and the normal responders (postprandial RLP-C level < or =7.5mg/dl, n=16). Significant increases in the level of both triglycerides and RLP-C were observed in the high responders. Basal FMD in the high responders (4.3+/-3.0%) was significantly lower than that in the normal responders (8.3+/-2.4%) (p<0.01), but FMD after the fat-loading in both groups did not change significantly. The change in RLP-C levels during the fat-loading test correlated significantly with basal FMD (r=-0.588, p<0.01). Multiple regression analysis showed a significant correlation between basal FMD and the change in RLP-C levels (r=-0.488, p<0.02). The results of this study suggest that postprandial RLP-C elevation could be associated with atherosclerotic progression even in normolipidemic subjects.
登录
查看更多内容
影响因子：
15.9
作者：
REAVEN, GM;CHEN, YDI;KRAUSS, RM
通讯作者：
KRAUSS, RM
使用载脂蛋白 B-100 单克隆抗体从人血浆中分离出富含甘油三酯的脂蛋白的载脂蛋白 E 富集组分的特性。
影响因子：
6.5
作者：
Campos,E;Nakajima,K;Tanaka,A;Havel,RJ
通讯作者：
Havel,RJ
影响因子：
2.8
作者：
Lieberman, EH;Gerhard, MD;Creager, MA
通讯作者：
Creager, MA
残余脂蛋白胆固醇和甘油三酯参考范围来自弗雷明汉心脏研究。
影响因子：
9.3
作者：
McNamara,JR;Shah,PK;Nakajima,K;Cupples,LA;Wilson,PW;Ordovas,JM;Schaefer,EJ
通讯作者：
Schaefer,EJ
DOI：
10.1016/0735-1097(95)00327-4
发表时间：
1995-11-01
影响因子：
24
作者：
ANDERSON, TJ;UEHATA, A;SELWYN, AP
通讯作者：
SELWYN, AP