The effects of cyclosporin A on T lymphocyte and dendritic cell sub‐populations in psoriasis
The effects of cyclosporin A on T lymphocyte and dendritic cell sub‐populations in psoriasis
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环孢素A对银屑病T淋巴细胞和树突状细胞亚群的影响
DOI：
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发表时间：
1987
影响因子：
10.3
通讯作者：
Lionel Fry
中科院分区：
文献类型：
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作者：
B. Baker;C. Griffiths;S. Lambert;A. Powles;J. Leonard;Helgi Valdimarsson;Lionel Fry
连续皮肤活检6例严重银屑病患者进行了研究，在治疗期间与环孢素。其中4名患者完全清除，其余2名患者表现出明显改善。在病变表皮中观察到树突状细胞亚群，HLA-DR+，但缺乏朗格汉斯细胞（DR+ 6-）特有的T6抗原。它们在治疗期间消失，在临床改善明显之前，并且以与银屑病清除相关的速率消失。这些细胞在正常或未受累的银屑病表皮中未发现，它们在皮损皮肤中的数量似乎与疾病的临床严重程度有关。在临床改善之前，表皮和真皮中的CD 4和CD 8以及HLA-DR + CD 8 T细胞的总数显著减少。相反，在消退期间，表皮中的HLA-DR + CD 4 T细胞的数量通常没有减少，而这些细胞在真皮中平均减少了68%。环孢菌素在银屑病中的有益作用进一步支持了T细胞在银屑病发病机制中发挥核心作用的假设。在环孢素治疗期间在皮肤中观察到的细胞变化可能有助于阐明该药物对人体免疫调节机制的影响。
Sequential skin biopsies from six patients with severe psoriasis were studied during treatment with cyclosporin. Four of the patients cleared completely and the remaining two showed a marked improvement. A subset of dendritic cells, HLA‐DR+ but lacking the T6 antigen characteristically expressed by Langerhans cells (DR+ 6‐), was observed in lesional epidermis. They disappeared during treatment, before clinical improvement was apparent and at a rate which correlated with clearance of psoriasis. These cells were not found in normal or uninvolved psoriatic epidermis and their number in lesional skin appeared to be related to the clinical severity of the disease. Total numbers of CD4 and CD8, and HLA‐DR+ CD8 T cells were substantially reduced in both epidermis and dermis prior to clinical improvement. In contrast, there was generally no decrease in the number of HLA‐DR + CD4 T cells in the epidermis during resolution, whereas these cells were reduced by an average of 68% in the dermis. The beneficial effects of cyclosporin in psoriasis further support the hypothesis that T cells play a central role in the pathogenesis of psoriasis. The cellular changes observed in the skin during cyclosporin treatment may help to elucidate the effects of this drug on immunoregulatory mechanisms in man.
表皮细胞源性胸腺细胞激活因子 (ETAF) 是一种有效的 T 细胞趋化剂。
DOI：
10.1111/1523-1747.ep12277126
发表时间：
1985
期刊：
The Journal of investigative dermatology
影响因子：
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作者：
Sauder,DN;Monick,MM;Hunninghake,GW
通讯作者：
Hunninghake,GW