The importance of long-lived proteins: Not just nuclear anymore.

The importance of long-lived proteins: Not just nuclear anymore.
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长寿命蛋白质的重要​​性:不再只是细胞核蛋白质。

DOI:
10.1016/j.devcel.2021.10.015
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发表时间:
2021
期刊:
影响因子:
11.8
通讯作者:
Erinjeri AP
Erinjeri AP
中科院分区:
生物学1区
文献类型:
--
作者:
Erinjeri AP

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线粒体长寿蛋白(mitolps)对组织健康的重要性十多年来一直是个谜。在本期的《发育细胞》中,Krishna等人证明了线粒体寿命是高度异质性的,mitolps通过促进电子传递链内的超复合体组装来促进呼吸能力。
The significance of mitochondrial long-lived proteins (mitoLLPs) to tissue health has remained mysterious for over a decade. In this issue ofDevelopmental Cell, Krishna et al. demonstrate that mitochondrial lifetimes are highly heterogeneous and that mitoLLPs promote respiratory capacity by facilitating supercomplex assembly within the electron transport chain.
DOI: 10.1016/j.cell.2013.07.037
发表时间: 2013-08-29
期刊: Cell
影响因子: 64.5
作者:
Toyama BH;Savas JN;Park SK;Harris MS;Ingolia NT;Yates JR 3rd;Hetzer MW
通讯作者: Hetzer MW