Clinical features and radiological characteristics of pulmonary cryptococcosis.
Clinical features and radiological characteristics of pulmonary cryptococcosis.
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肺隐球菌病的临床特征和影像学特征
DOI：
10.1177/0300060518769541
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Xue X
中科院分区：
文献类型：
--
作者：
Deng H;Zhang J;Li J;Wang D;Pan L;Xue X
目的肺隐球菌病诊断困难。在这项研究中，我们检查了提高肺隐球菌病诊断准确性的临床和放射学特征。方法回顾性分析2012 - 2016年3家三级医院68例肺隐球菌病患者的临床资料。结果68例患者中，39例（57.35%）无并发症，39例（57.35%）有临床症状，6例（8.82%）有职业暴露史，27例（39.71%）胸部ct表现为单发结节/肿块（肺隐球菌病最常见的类型），21例（30.88%）有多发结节/肿块，16例（23.53%）有或无结节的磨玻璃影，2例（2.94%）有军事结节，2例（2.94%）有纵隔淋巴结肿大。病变边缘不规则53例（77.94%），毛刺样病变33例（48.53%），支气管充气征32例（47.06%），空腔9例（13.24%），钙化4例（5.88%）。24例患者接受手术治疗，35例接受抗真菌治疗，9例接受两种治疗。结论本研究发现的临床特征和计算机断层扫描征象不能作为肺隐球菌病的诊断依据。因此，临床医生需要提高对肺隐球菌病的认识。
Objective Diagnosis of pulmonary cryptococcosis is difficult. In this study, we examined the clinical and radiological features that increase the diagnostic accuracy for pulmonary cryptococcosis. Methods This retrospective study included clinical data from 68 patients with pulmonary cryptococcosis from 2012 to 2016 in 3 tertiary hospitals. Results Among the 68 patients, 39 (57.35%) had no complications, 39 (57.35%) had clinical symptoms, 6 (8.82%) had a history of occupational exposure, 27 (39.71%) had a single nodule/mass (the most common type of pulmonary cryptococcosis) on chest computed tomography images, 21 (30.88%) had multiple nodules/masses, 16 (23.53%) had ground glass opacity with or without nodules, 2 (2.94%) had miliary nodules, and 2 (2.94%) had enlarged mediastinal lymph nodes. Fifty-three (77.94%) patients had lesions with irregular margins, 33 (48.53%) had spiculated lesions, 32 (47.06%) had air bronchograms, 9 (13.24%) had cavities, and 4 (5.88%) had calcifications. Twenty-four patients underwent surgery, 35 received antifungal treatment, and 9 received both treatments. Conclusion The clinical features and computed tomography signs found in this study are not specific for a diagnosis of pulmonary cryptococcosis. Therefore, an increased awareness of pulmonary cryptococcosis is needed among clinicians.
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影响因子：
3.8
作者：
Park, Benjamin J.;Wannemuehler, Kathleen A.;Chiller, Tom A.
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DOI：
10.1164/rccm.2008-740st
发表时间：
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