Cognition and quality of life in patients with carotid artery occlusion
Cognition and quality of life in patients with carotid artery occlusion
复制标题
颈动脉闭塞患者的认知和生活质量
作者：
F. C. Bakker;C. Klijn;J. V. D. Grond;L. Kappelle;A. Jennekens
背景资料：对于没有接受血运重建手术的症状性颈动脉闭塞患者的长期认知功能和生活质量（QoL）知之甚少。目的：评估这些患者的认知功能障碍病程和生活质量变化，以及脑代谢受损是否可预测认知功能的病程。研究方法：在一项为期1年的随访研究中，对73例TIA或与颈内动脉（伊卡）闭塞相关的轻微卒中患者的认知和健康相关生活质量进行了检查。通过MRI检查脑缺血性病变的存在;通过1H-MR波谱法测量症状性伊卡闭塞同侧半卵圆中心的代谢N-乙酰天冬氨酸/肌酸比值和乳酸盐的存在。结果：70%的中风患者和40%的TIA患者存在认知功能障碍。在随访期间复发性TIA患者中，认知功能保持在相同（受损）水平（平均受损评分：基线时0.7，1年随访时0.6; p = 0.646）。基线时无乳酸盐且随访期间无复发症状的患者，认知功能改善（平均损害评分：基线时1.1，1年随访时0.7; p < 0.001）。在12个月的随访中，自我感知的生活质量仍然受到影响，尽管影响程度不大（与正常评分的平均标准差<1）。结论：在有症状的伊卡闭塞患者中，如果没有进一步的症状发生并且患者在基线时没有乳酸盐，则在缺血事件后1.5年内认知功能改善。自我感知的生活质量仍然受到轻微影响。
Background: Little is known about long-term cognitive functioning and quality of life (QoL) in patients with symptomatic carotid artery occlusion who do not undergo revascularization surgery. Objective: To assess the course of cognitive impairment and changes in QoL in these patients and whether impaired cerebral metabolism predicts the course of cognitive functioning. Methods: In 73 consecutive patients with TIA or a minor stroke associated with an occlusion of the internal carotid artery (ICA), cognition and health-related QoL in a 1-year follow-up study were examined. The presence of cerebral ischemic lesions was examined by MRI; the metabolic N-acetyl aspartate/creatine ratio and the presence of lactate were measured by 1H-MR spectroscopy in the centrum semiovale ipsilateral to the symptomatic ICA occlusion. Results: Seventy percent of patients with a stroke and 40% of patients with a TIA were cognitively impaired. In patients with recurrent TIAs during follow-up, cognitive functioning remained at the same (impaired) level (mean impairment score: at baseline 0.7, at 1-year follow-up 0.6; p = 0.646). In patients without lactate at baseline and without recurrent symptoms during follow-up, cognitive functioning improved (mean impairment score: at baseline 1.1, at 1-year follow-up 0.7; p < 0.001). Self-perceived QoL remained affected at 12 months’ follow-up, although not to a large extent (mean SD from norm scores <1). Conclusions: In patients with a symptomatic ICA occlusion, cognitive functioning improved within 1.5 years after the ischemic event, if no further symptoms occurred and patients had no lactate at baseline. Self-perceived QoL remained slightly affected.
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
D. M. Moody;M. A. Bell;V. Challa;D. M. Moody1
通讯作者：
D. M. Moody;M. A. Bell;V. Challa;D. M. Moody1
影响因子：
11
作者：
TATEMICHI, TK;DESMOND, DW;BAGIELLA, E
通讯作者：
BAGIELLA, E