Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain.
Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain.
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DOI：
10.1083/jcb.152.6.1233
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发表时间：
2001-03-19
期刊：
影响因子：
--
通讯作者：
Javaherian K
中科院分区：
文献类型：
--
作者：
Kuo CJ;LaMontagne KR Jr;Garcia-Cardeña G;Ackley BD;Kalman D;Park S;Christofferson R;Kamihara J;Ding YH;Lo KM;Gillies S;Folkman J;Mulligan RC;Javaherian K
Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain conserved in vertebrates, Caenorhabditis elegans and Drosophila. Here, the c18 NC1 domain functioned as a motility-inducing factor regulating the extracellular matrix (ECM)-dependent morphogenesis of endothelial and other cell types. This motogenic activity required ES domain oligomerization, was dependent on rac, cdc42, and mitogen-activated protein kinase, and exhibited functional distinction from the archetypal motogenic scatter factors hepatocyte growth factor and macrophage stimulatory protein. The motility-inducing and mitogen-activated protein kinase–stimulating activities of c18 NC1 were blocked by its physiologic cleavage product ES monomer, consistent with a proteolysis-dependent negative feedback mechanism. These data indicate that the collagen XVIII NC1 region encodes a motogen strictly requiring ES domain oligomerization and suggest a previously unsuspected mechanism for ECM regulation of motility and morphogenesis.
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影响因子：
3.3
作者：
Kalman, D;Gomperts, SN;Bishop, JM
通讯作者：
Bishop, JM
DOI：
10.1073/pnas.92.19.8763
发表时间：
1995-09-12
影响因子：
11.1
作者：
MURAGAKI, Y;TIMMONS, S;OLSEN, BR
通讯作者：
OLSEN, BR
影响因子：
13.5
作者：
Musso, O;Rehn, M;Clément, B
通讯作者：
Clément, B
影响因子：
2.9
作者：
John, H;Preissner, KT;Ständker, L
通讯作者：
Ständker, L
影响因子：
11.4
作者：
Felbor, U;Dreier, L;Mothes, W
通讯作者：
Mothes, W