Curcumin: the spicy modulator of breast carcinogenesis.
Curcumin: the spicy modulator of breast carcinogenesis.
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姜黄素：乳腺癌发生的辛辣调节剂。
DOI：
10.1186/s13046-017-0566-5
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发表时间：
2017-07-19
期刊：
影响因子：
--
通讯作者：
Othman NH
中科院分区：
文献类型：
--
作者：
Banik U;Parasuraman S;Adhikary AK;Othman NH
在世界范围内，乳腺癌是女性最常见的癌症。多年来，临床医生和研究人员一直在研究和探索乳腺癌的各种治疗方法。然而，乳腺癌仍未被攻克，对治愈的探索仍在继续。目前的乳腺癌治疗和预防策略是多种药物的组合或调节多个靶点的药物。在这方面，天然产品正在成为重要的选择。姜黄素是一种很有前途的天然抗癌剂。这篇综述主要强调了姜黄素对癌症标志的调节作用。重点是其在乳腺癌发生的复杂途径中的抗癌作用。姜黄素通过其对细胞周期和增殖、凋亡、衰老、癌症扩散和血管生成的影响来调节乳腺癌的发生。其中NFkB、PI 3 K/Akt/mTOR、MAPK和JAK/STAT是主要的信号通路。本文还重点介绍了姜黄素介导的肿瘤微环境、肿瘤免疫、乳腺癌干细胞和癌症相关miRNAs的调节作用。使用姜黄素作为乳腺癌的治疗和预防剂是困惑的，其多样的生物活性，其中大部分仍然无法解释。这里回顾的信息应该指向未来姜黄素在乳腺癌研究中的潜在范围。
Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remained unconquered and the quest for cure is still going on. Present-day strategy of breast cancer therapy and prevention is either combination of a number of drugs or a drug that modulates multiple targets. In this regard natural products are now becoming significant options. Curcumin exemplifies a promising natural anticancer agent for this purpose. This review primarily underscores the modulatory effect of curcumin on the cancer hallmarks. The focus is its anticancer effect in the complex pathways of breast carcinogenesis. Curcumin modulates breast carcinogenesis through its effect on cell cycle and proliferation, apoptosis, senescence, cancer spread and angiogenesis. Largely the NFkB, PI3K/Akt/mTOR, MAPK and JAK/STAT are the key signaling pathways involved. The review also highlights the curcumin mediated modulation of tumor microenvironment, cancer immunity, breast cancer stem cells and cancer related miRNAs. Using curcumin as a therapeutic and preventive agent in breast cancer is perplexed by its diverse biological activity, much of which remains inexplicable. The information reviewed here should point toward potential scope of future curcumin research in breast cancer.
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影响因子：
2.5
作者：
Creighton, Chad J.;Chang, Jenny C.;Rosen, Jeffrey M.
通讯作者：
Rosen, Jeffrey M.
影响因子：
3.4
作者：
Chakraborty, Goutam;Jain, Shalini;Kundu, Gopal C.
通讯作者：
Kundu, Gopal C.
影响因子：
6.4
作者：
Banerjee K;Resat H
通讯作者：
Resat H
影响因子：
6.4
作者：
Beevers, Christopher S.;Li, Fengjun;Huang, Shile
通讯作者：
Huang, Shile
通过调节肿瘤微环境进行预防和治疗。
影响因子：
14.5
作者：
Casey SC;Amedei A;Aquilano K;Azmi AS;Benencia F;Bhakta D;Bilsland AE;Boosani CS;Chen S;Ciriolo MR;Crawford S;Fujii H;Georgakilas AG;Guha G;Halicka D;Helferich WG;Heneberg P;Honoki K;Keith WN;Kerkar SP;Mohammed SI;Niccolai E;Nowsheen S;Vasantha Rupasinghe HP;Samadi A;Singh N;Talib WH;Venkateswaran V;Whelan RL;Yang X;Felsher DW
通讯作者：
Felsher DW