Experience with oral mexiletine in primary erythromelalgia in children.
Experience with oral mexiletine in primary erythromelalgia in children.
复制标题
DOI：
10.4103/0256-4947.55316
复制
发表时间：
2009-07
影响因子：
1.6
通讯作者：
Bhat IN
中科院分区：
文献类型：
--
作者：
Iqbal J;Bhat MI;Charoo BA;Syed WA;Sheikh MA;Bhat IN
原发性红斑性肢痛症的特征是四肢灼痛、发红和发热。我们提出两例原发性红斑性肢痛症，他们都有几个月的严重烧伤疼痛的历史，在双手和双脚。两名患者均接受了多种止痛药治疗，症状无改善。将受影响部位放入冰冷的水中，导致受影响部位的浸泡损伤，从而缓解疼痛。两名患者都停止了参加学校和社会活动。我们尝试了口服美西律，一种Ib类抗心律失常药物，鉴于其在各种慢性疼痛疾病中的作用。使用后观察到显著改善。两名患者在使用几周后都有所改善，并且浸泡事件较少。我们没有观察到不良反应与mexilitine治疗。
Primary erythromelalgia is characterized by burning pain, redness, and warmth in the extremities. We present two cases of primary erythromelalgia both of whom presented with a history of several months of severe burning pain in both hands and feet. Both patients had received multiple pain medications with no improvement in symptoms. Pain was relieved by putting affected parts in ice cold water, which resulted in immersion injury of the affected parts. Both patients stopped taking part in school and social activities. We tried oral mexiletine, a class Ib antiarrythmic agent, in view of its reported role in various chronic painful conditions. Dramatic improvement was observed with its use. Both patients improved after several weeks of use, and there were fewer soaking episodes. We observed no adverse effects with mexilitine therapy.
登录
查看更多内容
影响因子：
--
作者：
Davis, MDP;O'Fallon, WM;Rooke, TW
通讯作者：
Rooke, TW
影响因子：
--
作者：
Kuhnert, SM;Phillips, WJ;Davis, MDP
通讯作者：
Davis, MDP
影响因子：
8.8
作者：
McGraw, T;Kosek, P
通讯作者：
Kosek, P
影响因子：
7.4
作者：
BACH, FW;JENSEN, TS;DEJGARD, A
通讯作者：
DEJGARD, A
影响因子：
8
作者：
Nathan, A;Rose, JB;Milovcich, K
通讯作者：
Milovcich, K