Insulin resistance alters islet morphology in nondiabetic humans.
Insulin resistance alters islet morphology in nondiabetic humans.
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DOI：
10.2337/db13-1013
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发表时间：
2014-03
期刊：
影响因子：
7.7
通讯作者：
Kulkarni RN
中科院分区：
文献类型：
--
作者：
Mezza T;Muscogiuri G;Sorice GP;Clemente G;Hu J;Pontecorvi A;Holst JJ;Giaccari A;Kulkarni RN
2型糖尿病的特征在于代谢组织中葡萄糖摄取不良，并且当胰岛素分泌不能科普恶化的胰岛素抵抗时表现出来。除了对骨骼肌、肝脏和脂肪组织代谢的影响外，胰岛素抵抗显然也影响胰腺β细胞。为了直接检查胰岛形态发生的改变作为胰岛素抵抗适应机制的一部分，我们评估了从胰岛素抵抗或胰岛素敏感的非糖尿病受试者的胰腺切除术中获得的胰腺样本。我们还比较了两组之间的胰岛素敏感性、胰岛素分泌和肠促胰岛素水平。我们报告了胰岛素抵抗组中胰岛大小增加，β和α细胞数量增加，导致β细胞-α细胞面积改变。我们在这一系列研究中的数据表明，在没有明显糖尿病的情况下，导管细胞的新生和α细胞的转分化是β细胞对胰岛素抵抗的代偿反应的潜在贡献者。
Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it is evident that insulin resistance also affects pancreatic β-cells. To directly examine the alterations that occur in islet morphology as part of an adaptive mechanism to insulin resistance, we evaluated pancreas samples obtained during pancreatoduodenectomy from nondiabetic subjects who were insulin-resistant or insulin-sensitive. We also compared insulin sensitivity, insulin secretion, and incretin levels between the two groups. We report an increased islet size and an elevated number of β- and α-cells that resulted in an altered β-cell–to–α-cell area in the insulin- resistant group. Our data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of α-cells are potential contributors to the β-cell compensatory response to insulin resistance in the absence of overt diabetes.
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影响因子：
7.7
作者：
Halperin F;Lopez X;Manning R;Kahn CR;Kulkarni RN;Goldfine AB
通讯作者：
Goldfine AB
影响因子：
4.8
作者：
Farilla, L;Bulotta, A;Perfetti, R
通讯作者：
Perfetti, R
影响因子：
8.2
作者：
Butler, A. E.;Cao-Minh, L.;Galasso, R.;Rizza, R. A.;Corradin, A.;Cobelli, C.;Butler, P. C.
通讯作者：
Butler, P. C.
影响因子：
16.2
作者：
Muscogiuri, Giovanna;Mezza, Teresa;Giaccari, Andrea
通讯作者：
Giaccari, Andrea
影响因子：
7.7
作者：
Li, YH;Cao, XM;Drucker, DJ
通讯作者：
Drucker, DJ