Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs.
Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs.
复制标题
颈动脉窦压力感受器调节狗的气管平滑肌张力。
DOI：
10.1161/01.res.60.3.337
复制
发表时间：
1987
影响因子：
20.1
通讯作者：
Coleridge,JC
中科院分区：
文献类型：
--
作者：
Schultz,HD;Pisarri,TE;Coleridge,HM;Coleridge,JC
已知动脉压力感受器会影响呼吸道平滑肌张力。因此，将颈动脉窦压力从20毫米汞柱增加到200毫米汞柱会导致反射性气管扩张。然而，在100毫米汞柱的正常动脉压设定点附近改变鼻窦压力的影响还没有被检验。在麻醉的人工呼吸犬中，我们用脉动压力扩张血管分离的颈动脉窦，并记录气管上段的等长张力。主动脉神经被切断。平均颈动脉窦压力在100至200毫米汞柱之间递增可降低气管张力、心率和动脉血压；在100至25毫米汞之间递减窦压则有相反的效果。当体动脉压保持不变时，改变颈动脉窦压力仍能引起气管反应。在恒定平均压附近增加和降低颈动脉窦脉压也会引起类似的气管张力变化。切断或冷却(0℃)颈动脉窦神经可消除所有反射效应；颈动脉压力感受器可消除气管反应，其幅度与刺激肺伸展感受器、喉感受器和肺C纤维所触发的反应相当。我们的结果表明，颈动脉窦压力感受器通过迷走胆碱能通路对上呼吸道产生紧张性影响，当血压在正常设定点附近变化时，会增加和降低气管平滑肌的张力。
Arterial baroreceptors are known to influence airway smooth muscle tone. Thus, increasing carotid sinus pressure from 20 to 200 mm Hg causes reflex tracheal dilation. However, the effects of changing sinus pressure around a normal arterial pressure set-point of 100 mm Hg have not been examined. In anesthetized, artificially ventilated dogs, we distended the vascularly isolated carotid sinuses with a pulsatile pressure and recorded isometric tension in an upper tracheal segment. The aortic nerves were cut. Increasing mean carotid sinus pressure in steps between 100 and 200 mm Hg decreased tracheal tension, heart rate, and arterial blood pressure; decreasing sinus pressure between 100 and 25 mm Hg had the opposite effect. Changing carotid sinus pressure still evoked tracheal responses when systemic arterial pressure was held constant. Increasing and decreasing carotid sinus pulse pressure around a constant mean pressure evoked similar changes in tracheal tension. All reflex effects were abolished by cutting or cooling (0 degree C) the carotid sinus nerves; tracheal responses were abolished by the carotid baroreflex were of comparable magnitude to those triggered by stimulating pulmonary stretch receptors, laryngeal receptors, and pulmonary C-fibers. Our results indicate that carotid sinus baroreceptors exert a tonic influence on the upper airways by a vagal cholinergic pathway, increasing and decreasing tracheal smooth muscle tension as blood pressure varies around the normal set-point.
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DOI：
--
发表时间：
1980
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
S. Lahiri;T. Nishino;A. Mokashi;E. Mulligan
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作者：
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M. Marcus
脑血管阻力的局部化学和神经源性调节。
影响因子：
33.6
作者：
W. Kuschinsky;M. Wahl
通讯作者：
M. Wahl
血气张力和颈动脉窦压力变化对气管容量和肺气流总阻力的影响
DOI：
--
发表时间：
1962
期刊：
Journal of Physiology
影响因子：
--
作者：
BY J. A. Nadel;J. G. WIDDICOMBEt
通讯作者：
J. G. WIDDICOMBEt
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DOI：
--
发表时间：
1966
期刊：
Journal of Physiology
影响因子：
--
作者：
J. Widdicombe
通讯作者：
J. Widdicombe