Inflammatory biomarkers and spontaneous preterm birth among obese women.
Inflammatory biomarkers and spontaneous preterm birth among obese women.
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肥胖妇女的炎症生物标志物和自发早产。
DOI：
10.3109/14767058.2015.1124083
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Shaw GM
中科院分区：
文献类型：
--
作者：
Wallenstein MB;Jelliffe-Pawlowski LL;Yang W;Carmichael SL;Stevenson DK;Ryckman KK;Shaw GM
确定肥胖妇女中孕中期血清炎症生物标志物与早产之间的关系。在这项巢式病例对照研究中，我们比较了妊娠导致早期自发性早产（妊娠< 32周，n=34）的肥胖妇女与妊娠导致足月分娩的肥胖妇女（n = 34）的65种血清炎症生物标志物。这些妇女是从一个更大的人口为基础的加州队列中选择的。随机森林和分类和回归树技术用于识别重要的生物标志物，并使用逻辑回归估计调整后的比值比（aOR）和95%置信区间（CI）。随机森林和分类回归树技术发现可溶性血管内皮生长因子受体3（sVEGFR 3）、可溶性白细胞介素2受体α链（sIL-2 RA）和可溶性肿瘤坏死因子受体1（sTNFR 1）与早产有关。使用多变量logistic回归比较早产病例和足月对照，血清sVEGFR 3水平降低和血清sIL-2 RA和sTNFR 1水平升高与肥胖妇女早产风险增加相关，aOR 3.2（95% CI 1.0-9.9）、aOR 2.8（95% CI 0.9-9.0）和aOR 4.1（95% CI 1.2 - 14.1）。在这项初步研究中，我们确定了三个血清生物标志物，表明炎症与肥胖妇女自发性早产有关：sVEGFR 3，sIL-2 RA和sTNFR 1。
To identify associations between second-trimester serum inflammatory biomarkers and preterm birth among obese women. In this nested case-control study, we compared 65 serum inflammatory biomarkers in obese women whose pregnancies resulted in early spontaneous preterm birth (< 32 weeks gestation, n=34) to obese women whose pregnancies resulted in term birth (n=34). These women were selected from a larger population-based California cohort. Random forest and classification and regression tree techniques were employed to identify biomarkers of importance, and adjusted odds ratios (aORs) and 95% confidence intervals (CI) were estimated using logistic regression. Random forest and classification and regression tree techniques found that soluble vascular endothelial growth factor receptor-3 (sVEGFR3), soluble interleukin-2 receptor alpha-chain (sIL-2RA), and soluble tumor necrosis factor receptor 1 (sTNFR1) were related to preterm birth. Using multivariable logistic regression to compare preterm cases and term controls, decreased serum levels of sVEGFR3 and increased serum levels of sIL-2RA and sTNFR1 were associated with increased risk of preterm birth among obese women, aOR 3.2 (95% CI 1.0–9.9), aOR 2.8 (95% CI 0.9–9.0), and aOR 4.1 (95% CI 1.2 – 14.1), respectively. In this pilot study, we identified three serum biomarkers indicative of inflammation to be associated with spontaneous preterm birth among obese women: sVEGFR3, sIL-2RA, and sTNFR1.
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