The role of early life genistein exposures in modifying breast cancer risk.
The role of early life genistein exposures in modifying breast cancer risk.
复制标题
生命早期接触金雀异黄素在改变乳腺癌风险中的作用。
DOI：
10.1038/sj.bjc.6604321
复制
发表时间：
2008-05-06
影响因子：
8.8
通讯作者：
Hilakivi-Clarke, L.
中科院分区：
文献类型：
--
作者：
Warri, A.;Saarinen, N. M.;Makela, S.;Hilakivi-Clarke, L.
Review of the existing literature suggests that consumption of soy foods or an exposure to a soy isoflavone genistein during childhood and adolescence in women, and before puberty onset in animals, reduces later mammary cancer risk. In animal studies, an exposure that is limited to the fetal period or adult life does not appear to have the same protective effect. A meta-analysis of human studies indicates a modest reduction in pre- and postmenopausal risk when dietary intakes are assessed during adult life. These findings concur with emerging evidence indicating that timing may be vitally important in determining the effects of various dietary exposures on the susceptibility to develop breast cancer. In this review, we address the mechanisms that might mediate the effects of an early life exposure to genistein on the mammary gland. The focus is on changes in gene expression, such as those involving BRCA1 and PTEN. It will be debated whether mammary stem cells are the targets of genistein-induced alterations and also whether the alterations are epigenetic. We propose that the effects on mammary gland morphology and signalling pathways induced by pubertal exposure to genistein mimic those induced by the oestrogenic environment of early first pregnancy.
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影响因子：
2.9
作者：
Day, JK;Besch-Williford, C;MacDonald, RS
通讯作者：
MacDonald, RS
影响因子：
4.3
作者：
Kim, Hyeon-A;Jeong, Kyu-Shik;Kim, Yoo Kyeong
通讯作者：
Kim, Yoo Kyeong
影响因子：
4.2
作者：
Lamartiniere, CA;Cotroneo, MS;Elgavish, A
通讯作者：
Elgavish, A
影响因子：
2.9
作者：
Luijten, M;Thomsen, AR;van Kreijl, CF
通讯作者：
van Kreijl, CF
影响因子：
4.7
作者：
Cabanes, A;Wang, M;Hilakivi-Clarke, L
通讯作者：
Hilakivi-Clarke, L