Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature.
Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature.
复制标题
DOI：
10.1016/j.jstrokecerebrovasdis.2020.105434
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Al-Mufti F
中科院分区：
文献类型：
--
作者：
Dakay K;Cooper J;Bloomfield J;Overby P;Mayer SA;Nuoman R;Sahni R;Gulko E;Kaur G;Santarelli J;Gandhi CD;Al-Mufti F
导致新型冠状病毒(新冠肺炎)感染的SARS-CoV-2病毒最近被发现与无数的血液系统紊乱有关；特别是在感染新冠肺炎的患者中，静脉血栓栓塞症的发生率异常高。据推测，病毒感染引起的细胞因子风暴或病毒与ACE-2受体结合引起的内皮损伤可能激活了导致高凝状态的级联反应。虽然肺栓塞和深静脉血栓形成在新冠肺炎感染的患者中已有很好的描述，但与新冠肺炎感染相关的脑静脉窦血栓形成(CVST)的文献很少。CVST是一种罕见的卒中病因，在女性和年轻人中发病率较高。我们报告了我们机构确诊的新冠肺炎感染和静脉窦血栓形成的三名患者，其中两名为男性，一名为女性。这些病例不属于CVST患者的典型人群，可能是由于新冠肺炎导致的过度粘连。这说明了在新冠肺炎感染患者中保持高怀疑指数的重要性，特别是那些原因不明的脑出血，或具有非典型动脉闭塞疾病模式的脑梗塞。
SARS-CoV-2, the virus responsible for novel Coronavirus (COVID-19) infection, has recently been associated with a myriad of hematologic derangements; in particular, an unusually high incidence of venous thromboembolism has been reported in patients with COVID-19 infection. It is postulated that either the cytokine storm induced by the viral infection or endothelial damage caused by viral binding to the ACE-2 receptor may activate a cascade leading to a hypercoaguable state. Although pulmonary embolism and deep venous thrombosis have been well described in patients with COVID-19 infection, there is a paucity of literature on cerebral venous sinus thrombosis (cVST) associated with COVID-19 infection. cVST is an uncommon etiology of stroke and has a higher occurrence in women and young people. We report a series of three patients at our institution with confirmed COVID-19 infection and venous sinus thrombosis, two of whom were male and one female. These cases fall outside the typical demographic of patients with cVST, potentially attributable to COVID-19 induced hypercoaguability. This illustrates the importance of maintaining a high index of suspicion for cVST in patients with COVID-19 infection, particularly those with unexplained cerebral hemorrhage, or infarcts with an atypical pattern for arterial occlusive disease.
登录
查看更多内容
影响因子：
8.8
作者：
Maatman, Thomas K.;Jalali, Farid;Meagher, Ashley D.
通讯作者：
Meagher, Ashley D.
DOI：
10.1016/j.jstrokecerebrovasdis.2020.104989
发表时间：
2020-08-01
影响因子：
2.5
作者：
Klein, David E.;Libman, Richard;Arora, Rohan
通讯作者：
Arora, Rohan
影响因子：
7.5
作者：
Lodigiani, Corrado;Iapichino, Giacomo;Barco, Stefano
通讯作者：
Barco, Stefano
影响因子：
4.3
作者：
Khan, Inayat Hussain;Savarimuthu, Sugeevan;Harky, Amer
通讯作者：
Harky, Amer
影响因子：
8.3
作者：
Yaghi, Shadi;Ishida, Koto;Frontera, Jennifer
通讯作者：
Frontera, Jennifer