HPV-related cancers after solid organ transplantation in the United States.
HPV-related cancers after solid organ transplantation in the United States.
复制标题
美国实体器官移植后的 HPV 相关癌症。
DOI：
10.1111/ajt.12472
复制
发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Engels EA
中科院分区：
文献类型：
--
作者：
Madeleine MM;Finch JL;Lynch CF;Goodman MT;Engels EA
Transplant recipients have elevated cancer risk including risk of human papillomavirus (HPV)-associated cancers of the cervix, anus, penis, vagina, vulva, and oropharynx. We examined the incidence of HPV-related cancers in 187,649 U.S. recipients in the Transplant Cancer Match Study. Standardized incidence ratios (SIRs) compared incidence rates to the general population, and incidence rate ratios (IRR) compared rates across transplant subgroups. We observed elevated incidence of HPV-related cancers (SIRs: in situ 3.3–20.3, invasive 2.2–7.3), except for invasive cervical cancer (SIR 1.0). Incidence increased with time since transplant for vulvar, anal, and penile cancers (IRRs 2.1–4.6 for 5+ vs. <2 years). Immunophenotype, characterized by decreased incidence with HLA DRB1:13 and increased incidence with B:44, contributed to susceptibility at several sites. Use of specific immunosuppressive medications was variably associated with incidence; for example, tacrolimus, was associated with reduced incidence for some anogenital cancers (IRRs 0.4–0.7) but increased incidence of oropharyngeal cancer (IRR 2.1). Thus, specific features associated with recipient characteristics, transplanted organs, and medications are associated with incidence of HPV-related cancers after transplant. The absence of increased incidence of invasive cervical cancer highlights the success of cervical screening in this population and suggests a need for screening of other HPV-related cancers.
登录
查看更多内容
影响因子：
6.2
作者：
Opelz, Gerhard;Doehler, Bernd
通讯作者：
Doehler, Bernd
影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
影响因子：
11.2
作者：
Madeleine, Margaret M.;Johnson, Lisa G.;Galloway, Denise A.
通讯作者：
Galloway, Denise A.
影响因子：
5.5
作者：
Moscicki, Anna-Barbara;Schiffman, Mark;Villa, Luisa L.
通讯作者：
Villa, Luisa L.
影响因子：
2.1
作者：
Mathew, T;Kreis, H;Friend, P
通讯作者：
Friend, P