Salidroside Attenuates Hypoxia-Induced Expression of Connexin 43 in Corpus Cavernosum Smooth Muscle Cells
Salidroside Attenuates Hypoxia-Induced Expression of Connexin 43 in Corpus Cavernosum Smooth Muscle Cells
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红景天苷减弱缺氧诱导的海绵体平滑肌细胞中连接蛋白 43 的表达
DOI：
10.1159/000507099
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发表时间：
2020-07
影响因子：
1.6
通讯作者：
Lv Bodong
中科院分区：
文献类型：
--
作者：
Zhao Jianfeng;Zhao Fan;Ye Miaoyong;Ma Ke;Huang Wenjie;Qian Le;Huang Xiaojun;Fu Huiyin;Lv Bodong
Introduction:Connexin 43 (Cx43) is the major component of gap junction in corpus cavernosum smooth muscle, which allows rapid intercellular communication. Cx43 coordinates corpus cavernosum smooth muscle cells and ensures erectile function. The role of hypoxia in Cx43 dysfunction resulting in erectile dysfunction has not been well studied, and salidroside has shown cell protective effects under hypoxia.Objective:We aimed to investigate the protective role of salidroside and the underlying mechanisms in hypoxia-induced dysfunction of Cx43.Methods:Corpus cavernosum smooth muscle cells prepared from young male Sprague-Dawley rats were pretreated with or without salidroside and exposed to hypoxic condition for 48 h. The cell viability, expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and Cx43, and Ca2+ signals were investigated.Results:Pretreatment with salidroside attenuated loss of hypoxia-induced cell viability markedly and could downregulate the HIF-1 alpha protein expression under hypoxia. Moreover, the expression of Cx43 was significantly increased by hypoxia but was decreased with salidroside pretreatment. The salidroside pretreated group exhibited enhanced release of intracellular Ca2+ in corpus cavernosum smooth muscle cells compared with the hypoxia group after stimulation.Conclusion:Salidroside has a protective effect against hypoxia-induced damage to corpus cavernosum smooth muscle cells.
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影响因子：
1.5
作者：
Danon, Asaf;Zeevi-Levin, Naama;Binah, Ofer
通讯作者：
Binah, Ofer
DOI：
10.1016/j.biocel.2006.03.007
发表时间：
2006-01-01
影响因子：
4
作者：
Pointis, Georges
通讯作者：
Pointis, Georges
影响因子：
4.5
作者：
Aytaç;Mckinlay;Krane
通讯作者：
Aytaç;Mckinlay;Krane
DOI：
10.1007/978-1-59745-489-6_25
发表时间：
2009
期刊：
--
影响因子：
--
作者：
G. Pointis;C. Fiorini;J. Gilleron;D. Carette;D. Segretain
通讯作者：
G. Pointis;C. Fiorini;J. Gilleron;D. Carette;D. Segretain
DOI：
--
发表时间：
2001-06
期刊：
Alternative medicine review : a journal of clinical therapeutic
影响因子：
--
作者：
G. Kelly
通讯作者：
G. Kelly