Microstructural constitutive model of active coronary media.
Microstructural constitutive model of active coronary media.
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DOI：
10.1016/j.biomaterials.2013.06.035
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发表时间：
2013-10
期刊：
影响因子：
14
通讯作者：
Kassab, Ghassan S.
中科院分区：
文献类型：
--
作者：
Chen, Huan;Luo, Tong;Zhao, Xuefeng;Lu, Xiao;Huo, Yunlong;Kassab, Ghassan S.
尽管血管平滑肌细胞（VSMC）在生理学和病理学中至关重要，但缺乏这些细胞的详细形态学数据。本研究的目的是确定猪冠状动脉 VSMC 的尺寸（宽度和长度）和方向，并开发活性介质的微观结构本构模型。发现在零应力状态下测量的 VSMC 的尺寸、空间纵横比和方向角遵循连续正态（或双峰正态）分布。 VSMCs偏离血管周向排列，极角对称18.7°±10.9°，局部VSMC变形与组织水平变形相似。基于 VSMC 几何和变形特征的实验测量，开发了一种基于微结构的主动本构模型来预测冠状动脉中膜的双轴血管活性。结果表明，血管的轴向主动反应与多轴收缩以及斜向VSMC排列有关。目前的形态学数据库对于开发精确的结构模型至关重要，并且对于理解肌肉血管的生物力学具有重要意义。
Although vascular smooth muscle cells (VSMCs) are pivotal in physiology and pathology, there is a lack of detailed morphological data on these cells. The objective of this study was to determine dimensions (width and length) and orientation of swine coronary VSMCs and to develop a microstructural constitutive model of active media. The dimensions, spatial aspect ratio and orientation angle of VSMCs measured at zero-stress state were found to follow continuous normal (or bimodal normal) distributions. The VSMCs aligned off circumferential direction of blood vessels with symmetrical polar angles 18.7°±10.9°, and the local VSMC deformation was affine with tissue-level deformation. A microstructure-based active constitutive model was developed to predict the biaxial vasoactivity of coronary media, based on experimental measurements of geometrical and deformation features of VSMCs. The results revealed that the axial active response of blood vessels is associated with multi-axial contraction as well as oblique VSMC arrangement. The present morphological data base is essential for developing accurate structural models and is seminal for understanding the biomechanics of muscular vessels.
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DOI：
10.1115/1.4004249
发表时间：
2011-06
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Hollander Y;Durban D;Lu X;Kassab GS;Lanir Y
通讯作者：
Lanir Y
影响因子：
8.3
作者：
Gaballa, MA;Jacob, CT;Goldman, S
通讯作者：
Goldman, S
影响因子：
2.4
作者：
Hayman, Danika M.;Zhang, Jinzhou;Han, Hai-Chao
通讯作者：
Han, Hai-Chao
影响因子：
6.9
作者：
O'Connell, Mary K.;Murthy, Sushila;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
影响因子：
--
作者：
AZUMA, T;OKA, S
通讯作者：
OKA, S