Parkinson's disease treatment: past, present, and future.

Parkinson's disease treatment: past, present, and future.
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DOI:
10.1007/s00702-020-02167-1
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发表时间:
2020-05
期刊:
Journal of neural transmission (Vienna, Austria : 1996)
影响因子:
--
通讯作者:
Elsworth JD
Elsworth JD
中科院分区:
其他
文献类型:
--
作者:
Elsworth JD

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杰拉尔德·斯特恩博士过去和目前的治疗帕金森病患者的实质性贡献进行审查,形成未来的选择,以控制症状和停止疾病的进展进行评估的基础。这些机会将取决于对环境、遗传和表观遗传对疾病发作的影响的相对贡献的更好理解,并有望成为改善线粒体功能、阻止突触核蛋白和神经黑色素积累以及改进干细胞和基因疗法的策略。这些进展将通过部署改进的疾病模型来实现。
The substantial contributions of Dr Gerald Stern to past and current treatments for Parkinson’s disease patients is reviewed, which form the foundation for an evaluation of future options to control symptoms and halt progression of the disease. These opportunities will depend on a greater understanding of the relative contributions of the environment, genetic and epigenetic influences to disease onset, and promise to emerge as strategies for improving mitochondrial function, halting synuclein and neuromelanin accumulation, in addition to refinement of stem cell and gene therapies. Such advances will be achieved through deployment of improved models for the disease.
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