BDNF mediates adaptive brain and body responses to energetic challenges.
BDNF mediates adaptive brain and body responses to energetic challenges.
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DOI：
10.1016/j.tem.2013.10.006
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发表时间：
2014-02
影响因子：
10.9
通讯作者：
Mattson, Mark P.
中科院分区：
文献类型：
--
作者：
Marosi, Krisztina;Mattson, Mark P.
关键词：
新的研究结果表明，脑源性神经营养因子（BDNF）在调节能量稳态中发挥着广泛的作用，它通过控制进食模式和身体活动，并通过调节外周组织的葡萄糖代谢。BDNF介导能量挑战（如剧烈运动和禁食）对认知、情绪、心血管功能和外周代谢的有益影响。通过刺激葡萄糖转运和线粒体生物发生，BDNF增强细胞生物能量并保护神经元免受损伤和疾病。通过作用于大脑和外周，BDNF增加胰岛素敏感性和副交感神经张力。遗传因素，“沙发土豆”的生活方式和慢性压力损害BDNF信号，这可能有助于代谢综合征的发病机制。针对肥胖、糖尿病和神经系统疾病的新型bdnf干预措施正在开发中。
Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues. BDNF mediates beneficial effects of energetic challenges such as vigorous exercise and fasting on cognition, mood, cardiovascular function and peripheral metabolism. By stimulating glucose transport and mitochondrial biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease. By acting in the brain and periphery, BDNF increases insulin sensitivity and parasympathetic tone. Genetic factors, a ‘couch potato’ lifestyle and chronic stress impair BDNF signaling, which may contribute to the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are being developed for obesity, diabetes and neurological disorders.
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影响因子：
3.7
作者：
Banni S;Carta G;Murru E;Cordeddu L;Giordano E;Marrosu F;Puligheddu M;Floris G;Asuni GP;Cappai AL;Deriu S;Follesa P
通讯作者：
Follesa P
影响因子：
5.3
作者：
Goshen, Inbal;Avital, Avi;Yirmiya, Raz
通讯作者：
Yirmiya, Raz
DOI：
10.1523/jneurosci.4907-12.2013
发表时间：
2013-03-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Briz V;Hsu YT;Li Y;Lee E;Bi X;Baudry M
通讯作者：
Baudry M
DOI：
10.1523/jneurosci.4515-11.2012
发表时间：
2012-04-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Dean C;Liu H;Staudt T;Stahlberg MA;Vingill S;Bückers J;Kamin D;Engelhardt J;Jackson MB;Hell SW;Chapman ER
通讯作者：
Chapman ER
影响因子：
4.2
作者：
Griffioen, Kathleen J.;Wan, Ruiqian;Mattson, Mark P.
通讯作者：
Mattson, Mark P.