Vagus nerve stimulation reduces body weight and fat mass in rats.
Vagus nerve stimulation reduces body weight and fat mass in rats.
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DOI：
10.1371/journal.pone.0044813
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Follesa P
中科院分区：
文献类型：
--
作者：
Banni S;Carta G;Murru E;Cordeddu L;Giordano E;Marrosu F;Puligheddu M;Floris G;Asuni GP;Cappai AL;Deriu S;Follesa P
在迷走神经刺激（VNS）作为耐药性癫痫患者的附加治疗的多种作用中，在一些个体中观察到体重中度减轻。我们现在已经在大鼠中研究了这种效应。与假手术对照动物相比，大鼠暴露于VNS 4周降低了饲料转化效率以及体重增加（减少25%）和肠系膜脂肪组织量（减少45%）。一个配对喂养的实验表明，无论是降低饮食摄入量和增加能量消耗独立地有助于体重和肠系膜脂肪组织的减少。此外，迷走神经刺激使血浆和肠系膜脂肪组织中的非酯化脂肪酸水平分别增加了50%和80%，而不影响肝脏中的非酯化脂肪酸水平。此外，VNS减少了内源性大麻素的量，并增加了N-棕榈酰乙醇酰胺，这是肠系膜脂肪组织中转录因子PPARα（过氧化物酶体增殖物激活受体α）的内源性配体，但下丘脑中没有。这些作用伴随着下丘脑中脑源性神经营养因子（BDNF）基因表达的增加和肝脏中PPARα丰度的上调。我们的研究结果表明，减少体脂肪诱导VNS大鼠可能是由于中枢和外周介质的作用。与VNS相关的饲料转化效率降低可能是由下丘脑BDNF介导的，肠系膜脂肪组织中内源性大麻素张力的下调和肝脏中脂肪酸氧化的PPARα依赖性增加，这可能是协同作用的原因。
Among the manifold effects of vagus nerve stimulation (VNS) delivered as an add-on treatment to patients with drug-resistant epilepsy, a moderate loss of body weight has been observed in some individuals. We have now investigated this effect in rats. Exposure of rats to VNS for 4 weeks reduced feed conversion efficiency as well as body weight gain (by ∼25%) and the amount of mesenteric adipose tissue (by ∼45%) in comparison with those in sham-operated control animals. A pair-fed experiment showed that both lower dietary intake and increase energy expenditure independently contributed to the reduction of body weight and mesenteric adipose tissue. Moreover, VNS increased the level of non-esterified fatty acids in plasma and mesenteric adipose tissue by ∼50 and 80%, respectively, without affecting that in the liver. In addition, VNS reduced the amounts of endocannabinoids and increased N-palmitoylethanolamide, an endogenous ligand of the transcription factor PPARα (peroxisome proliferator–activated receptor α) in mesenteric adipose tissue but not in the hypothalamus. These effects were accompanied by increased expression of the gene for brain-derived neurotrophic factor (BDNF) in the hypothalamus and up-regulation of the abundance of PPARα in the liver. Our results suggest that the reduction in body fat induced by VNS in rats may result from the action of both central and peripheral mediators. The reduced feed conversion efficiency associated with VNS may be mediated by hypothalamic BDNF, down-regulation of endocannabinoid tone in mesenteric adipose tissue and a PPARα-dependent increase in fatty acid oxidation in the liver, which in concerted action may account for the anorexic effect and increased energy expenditure.
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DOI：
10.1523/jneurosci.1786-08.2008
发表时间：
2008-10-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lubin FD;Roth TL;Sweatt JD
通讯作者：
Sweatt JD
影响因子：
64.8
作者：
Fu, J;Gaetani, S;Piomelli, D
通讯作者：
Piomelli, D
影响因子：
7.7
作者：
Engeli, S;Böhnke, J;Jordan, J
通讯作者：
Jordan, J
影响因子：
3.6
作者：
Lo Verme, J;Fu, J;Piomelli, D
通讯作者：
Piomelli, D
影响因子：
2.6
作者：
Koren, MS;Holmes, MD
通讯作者：
Holmes, MD