Functional adaptation of cortical interneurons to attenuated activity is subtype-specific.
Functional adaptation of cortical interneurons to attenuated activity is subtype-specific.
复制标题
皮质间神经元对减弱活性的功能适应性是亚型特异性的。
DOI：
10.3389/fncir.2012.00066
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发表时间：
2012
影响因子：
3.5
通讯作者：
Fishell GJ
中科院分区：
文献类型：
--
作者：
Karayannis T;De Marco García NV;Fishell GJ
功能神经元动态平衡已经在各种模型系统和环境中进行了研究。许多研究表明，在单个细胞或网络中可以激活许多变化，以补偿活动水平的扰动或变化。由于很难在体内稀疏地靶向特定的神经元群体，因此将细胞自主从网络介导的事件中分离出来是复杂的。在这里，我们利用我们最近开发的体内方法，允许稀疏标记和操纵浅尾侧神经节隆起(CGE)衍生的GABA能中间神经元的活动。内向整流钾通道Kir2.1细胞的表达自主地降低了神经元的活动，并导致其内在电生理特性和接受的突触输入的特定发育变化。与以前关于锥体细胞内稳态伸缩的研究不同，我们没有在这些中间神经元中检测到任何典型的代偿机制。相反，我们在表达reelin的中间神经元亚群中看到了兴奋性突触事件动力学的特定变化。这些结果为中间神经元细胞自主调节兴奋性的能力提供了第一次活体观察。
Functional neuronal homeostasis has been studied in a variety of model systems and contexts. Many studies have shown that there are a number of changes that can be activated within individual cells or networks in order to compensate for perturbations or changes in levels of activity. Dissociating the cell autonomous from the network-mediated events has been complicated due to the difficulty of sparsely targeting specific populations of neurons in vivo. Here, we make use of a recent in vivo approach we developed that allows for the sparse labeling and manipulation of activity within superficial caudal ganglionic eminence (CGE)-derived GABAergic interneurons. Expression of the inward rectifying potassium channel Kir2.1 cell-autonomously reduced neuronal activity and lead to specific developmental changes in their intrinsic electrophysiological properties and the synaptic input they received. In contrast to previous studies on homeostatic scaling of pyramidal cells, we did not detect any of the typically observed compensatory mechanisms in these interneurons. Rather, we instead saw a specific alteration of the kinetics of excitatory synaptic events within the reelin-expressing subpopulation of interneurons. These results provide the first in vivo observations for the capacity of interneurons to cell-autonomously regulate their excitability.
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