Expert opinion on pharmacotherapy of kidney disease in HIV-infected patients.
Expert opinion on pharmacotherapy of kidney disease in HIV-infected patients.
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DOI：
10.1517/14656566.2011.535518
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发表时间：
2011-04
影响因子：
3.2
通讯作者：
Ross MJ
中科院分区：
文献类型：
--
作者：
Alsauskas ZC;Medapalli RK;Ross MJ
人类免疫缺陷病毒（HIV）感染与多种肾脏疾病的发生有关。 HIV 相关肾病 (HIVAN) 是 HIV 感染者慢性肾病 (CKD) 的最常见原因，主要影响非洲血统的患者。 HIVAN 是非洲裔美国人终末期肾病 (ESRD) 的主要原因。 HIV 感染者肾脏疾病谱的概述；目前治疗艾滋病毒肾病的药物干预措施。有关 HIV 感染者肾脏疾病最常见原因的知识以及与 HIV 感染者肾脏疾病药物治疗相关的原则。肾脏疾病是艾滋病毒感染者发病和死亡的重要原因，该人群中慢性肾脏病的最常见原因是艾滋病毒相关肾病，它是由肾上皮病毒感染引起的。 HIV感染者常用的几种药物可能会对肾脏产生不良影响，对于肾功能受损的患者，需要调整许多抗逆转录病毒药物的剂量。
Human immunodeficiency virus (HIV) infection is associated with the development of a wide spectrum of kidney diseases. HIV-associated nephropathy (HIVAN) is the most common cause of chronic kidney disease (CKD) in HIV-infected individuals and predominantly affects patients of African ancestry. HIVAN is a leading cause of end-stage renal disease (ESRD) among African-Americans. an overview of the spectrum of kidney disease in patients with HIV; current pharmacologic interventions to treat kidney disease in HIV. Knowledge regarding the most common causes of kidney disease in HIV-infected patients and principals related to pharmacotherapy in HIV-infected patients with kidney disease. Kidney disease is an important cause of morbidity and mortality in HIV-infected patients and the most common cause of chronic kidney disease in this population is HIV-associated nephropathy, which is caused by viral infection of the renal epithelium. Several medications that are commonly used in HIV-infected patients can have adverse effects on the kidneys and the doses of many antiretroviral medications need to be adjusted in patients with impaired renal function.
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