The Role of the Membrane in Transporter Folding and Activity.
The Role of the Membrane in Transporter Folding and Activity.
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DOI：
10.1016/j.jmb.2021.167103
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发表时间：
2021-08-06
影响因子：
5.6
通讯作者：
Robertson JL
中科院分区：
文献类型：
--
作者：
Ernst M;Robertson JL
膜转运蛋白的合成、折叠和功能是确定细胞生理学的关键因素。由于这些蛋白质的稳定性是在脂质双层中形成的，难怪我们发现许多这些膜蛋白以某种方式表现出其结构或活性与膜的偶联。越来越多的转运蛋白结构正在通过一些关于周围膜的信息来确定，计算模型正在提供关于这些溶剂化结构的进一步的分子细节。因此，该领域正朝着确定哪些分子机制-脂类相互作用、膜扰动、差异溶剂化和体膜效应-将膜能量学与转运蛋白的稳定性和功能联系起来。在这篇综述中，我们概述了这些机制和越来越多的证据表明，脂质双层是膜运输蛋白折叠、形式和功能的主要决定因素。
The synthesis, folding, and function of membrane transport proteins are critical factors for defining cellular physiology. Since the stability of these proteins evolved amidst the lipid bilayer, it is no surprise that we are finding that many of these membrane proteins demonstrate coupling of their structure or activity in some way to the membrane. More and more transporter structures are being determined with some information about the surrounding membrane, and computational modeling is providing further molecular details about these solvation structures. Thus, the field is moving towards identifying which molecular mechanisms - lipid interactions, membrane perturbations, differential solvation, and bulk membrane effects, are involved in linking membrane energetics to transporter stability and function. In this review, we present an overview of these mechanisms and the growing evidence that the lipid bilayer is a major determinant of the fold, form, and function of membrane transport proteins in membranes.
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