Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives.
Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives.
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DOI：
10.3390/ijms21228495
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发表时间：
2020-11-11
影响因子：
5.6
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Dai X;Wu G;Zhang Y;Zhang X;Yin R;Qi X;Li J;Jiang T
A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extremely poor water solubility and adverse side effects. Here, two series of novel 20-substituted (20S)-10,11-methylenedioxy-camptothecin coupled with 5-substituted uracils and other heterocyclic rings through glycine were synthesized. All the derivatives showed superior cytotoxic activities in vitro with IC50 values in the nanomolar range. Among them, 12e displayed higher cytotoxic activities in several cancer cell lines with better water solubility than FL118. Our results further showed that, like FL118, 12e inhibited cell proliferation resulting from cell cycle arrest and apoptosis by blocking the anti-apoptotic gene transcription of survivin, Mcl-1, Bcl-2, and XIAP in both A549 cells and NCI-H446 cells. Furthermore, 12e did not show any inhibitory activity on Topo I, which is involved in hematopoietic toxicity. In vivo, 12e showed similar antitumor efficacy to FL118 but lower toxicity. Our findings indicate that 12e is a promising therapeutic agent for cancer treatment, and the core structure of FL118 represents a promising platform to generate novel FL118-based antitumor drugs.
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影响因子：
6.4
作者：
Bray, F.;Ferlay, J.;Forman, D.
通讯作者：
Forman, D.
影响因子：
7.3
作者：
Lerchen, HG;Baumgarten, J;Fiebig, HH
通讯作者：
Fiebig, HH
DOI：
10.1109/access.2023.3293001
发表时间：
--
期刊：
IEEE Access
影响因子：
3.6
作者：
Yi-Ming Tseng; Bang-Ren Chen; Wei-Cheng Lin; Wen-Jay Lee; Nan-Yow Chen; Tian-Li Wu
通讯作者：
Yi-Ming Tseng
影响因子：
3.7
作者：
Ling X;Cao S;Cheng Q;Keefe JT;Rustum YM;Li F
通讯作者：
Li F
DOI：
10.1016/0002-9378(72)90109-3
发表时间：
1972-01-01
影响因子：
9.8
作者：
DISAIA, PJ;RUTLEDGE, FN;SINKOVICS, JG
通讯作者：
SINKOVICS, JG