The Human Eye Proteome Project: Updates on an Emerging Proteome.
The Human Eye Proteome Project: Updates on an Emerging Proteome.
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DOI：
10.1002/pmic.201700394
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发表时间：
2018-03
期刊：
影响因子：
3.4
通讯作者：
Semba RD
中科院分区：
文献类型：
--
作者：
Ahmad MT;Zhang P;Dufresne C;Ferrucci L;Semba RD
人眼是由多个隔室组成的复杂器官，这些隔室具有反映其不同功能的独特和专门的特性。虽然在过去的十年中，眼部成像和治疗方法取得了进展，但许多常见眼部疾病的发病机制仍然知之甚少。蛋白质组学是一个非常宝贵的工具，以了解发病机制，诊断和治疗眼病。到2013年，当人眼蛋白质组计划（也称为EyeOme）成立时，在人眼中发现了4842种非冗余蛋白质。在PubMed检索中确定了23篇关于人眼蛋白质组的最新论文。这些论文被用来编辑人类眼睛中9782种非冗余蛋白质的更新资源。这个更新的目录揭示了以前未描述的蛋白质组在人眼内的分子组成，包括视神经，巩膜，虹膜和睫状体，同时添加额外的蛋白质到以前表征的蛋白质组，如房水，透镜，玻璃体，视网膜和视网膜色素上皮细胞/脉络膜。虽然在表征人眼完整蛋白质组方面已经取得了相当大的进展，但还需要额外的高质量数据来确认和量化先前发现的健康和疾病中的眼睛蛋白质。
The human eye is a complex organ consisting of multiple compartments with unique and specialized properties that reflect their varied functions. Although there have been advancements in ocular imaging and therapeutics over the past decade, the pathogenesis of many common eye diseases remains poorly understood. Proteomics is an invaluable tool to gain insight into pathogenesis, diagnosis, and treatment of eye diseases. By 2013, when the Human Eye Proteome Project (also known as the EyeOme) was founded, there were 4842 nonredundant proteins identified in the human eye. Twenty-three recent papers on the human eye proteome were identified in PubMed searches. These papers were used to compile an updated resource of 9782 nonredundant proteins in the human eye. This updated catalogue sheds light on the molecular makeup of previously undescribed proteomes within the human eye, including optic nerve, sclera, iris, and ciliary body, while adding additional proteins to previously characterized proteomes such as aqueous humor, lens, vitreous, retina, and retinal pigment epithelium/choroid. Although considerable advances have been made to characterize the complete proteome of the human eye, additional high-quality data are needed to confirm and quantify previously discovered eye proteins in both health and disease.
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DOI：
10.1111/j.1600-0420.2005.00381.x
发表时间：
2005-02-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Funding, M;Vorum, H;Ehlers, N
通讯作者：
Ehlers, N
影响因子：
3.3
作者：
Csosz, Eva;Boross, Peter;Tozser, Jozsef
通讯作者：
Tozser, Jozsef
影响因子：
4.4
作者：
Chowdhury, Uttio Roy;Madden, Benjamin J.;Fautsch, Michael P.
通讯作者：
Fautsch, Michael P.
DOI：
10.1073/pnas.222551899
发表时间：
2002-11-12
影响因子：
11.1
作者：
Crabb, JW;Miyagi, M;Hollyfield, JG
通讯作者：
Hollyfield, JG
影响因子：
3.4
作者：
Chan, Alfred W. H.;Ho, Ye-shih;Chung, Stephen S. M.
通讯作者：
Chung, Stephen S. M.