Experimental assessment of microwave ablation computational modeling with MR thermometry.
Experimental assessment of microwave ablation computational modeling with MR thermometry.
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DOI：
10.1002/mp.14318
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发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Prakash P
中科院分区：
文献类型：
--
作者：
Faridi P;Keselman P;Fallahi H;Prakash P
计算模型在微波消融（MWA）器械的设计和表征过程中被广泛使用，并已被提议用于治疗前规划。我们的目的是评估三维瞬态温度和消融曲线预测MWA计算模型与温度曲线实验测量使用磁共振（MR）测温在离体牛肝。我们在MR引导下使用定制的2.45 GHz水冷式施源器在离体组织中进行MWA。在加热前2 min、微波暴露5-10 min期间和加热后3 min采集MR温度测定数据。光纤温度传感器用于验证MR温度测量的准确性。在施加器输入端使用30 - 50 W的施加功率进行了总共13次消融实验。MWA计算模型使用有限元法实现，并纳入组织物理特性的温度依赖性变化。使用Dice相似系数（DSC）将模型预测的消融区范围与MRI衍生的Arrhenius热损伤图进行比较。在加热之前，观察到的MR温度数据的标准偏差在0.3 - 0.7 °C的范围内。在加热过程中，MR温度测量值与光纤温度探头之间的平均绝对误差在0.5 - 2.8 °C范围内。13个实验装置的模型预测的消融区和MRI衍生的Arrhenius热损伤图之间的平均DSC为0.95。当比较模拟和实验（即使用MRI）测量温度时，相对于最大温度变化的平均绝对误差（MAE %）在5%-8.5%范围内。我们开发了一个系统，用于表征三维瞬态温度和消融轮廓与MR测温在MWA在离体肝组织，并应用该系统MWA计算模型的实验验证。
Computational models are widely used during the design and characterization of microwave ablation (MWA) devices, and have been proposed for pre-treatment planning. Our objective was to assess 3D transient temperature and ablation profiles predicted by MWA computational models with temperature profiles measured experimentally using magnetic resonance (MR) thermometry in ex vivo bovine liver. We performed MWA in ex vivo tissue under MR-guidance using a custom, 2.45 GHz water-cooled applicator. MR thermometry data were acquired for 2 min prior to heating, during 5–10 min microwave exposures, and for 3 min following heating. Fiber-optic temperature sensors were used to validate the accuracy of MR temperature measurements. A total of 13 ablation experiments were conducted using 30 – 50 W applied power at the applicator input. MWA computational models were implemented using the finite element method, and incorporated temperature-dependent changes in tissue physical properties. Model-predicted ablation zone extents were compared against MRI-derived Arrhenius thermal damage maps using the Dice similarity coefficient (DSC). Prior to heating, the observed standard deviation of MR temperature data was in the range of 0.3 – 0.7 °C. Mean absolute error between MR temperature measurements and fiber-optic temperature probes during heating was in the range of 0.5 – 2.8 °C. The mean DSC between model-predicted ablation zones and MRI-derived Arrhenius thermal damage maps for 13 experimental set-ups was 0.95. When comparing simulated and experimentally (i.e. using MRI) measured temperatures, the mean absolute error (MAE %) relative to maximum temperature change was in the range 5 % - 8.5 %. We developed a system for characterizing 3D transient temperature and ablation profiles with MR thermometry during MWA in ex vivo liver tissue, and applied the system for experimental validation of MWA computational models.
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影响因子：
1.4
作者：
Fallahi, Hojjatollah;Clausing, Daniel;Prakash, Punit
通讯作者：
Prakash, Punit
DOI：
10.3109/02656736.2013.799295
发表时间：
2013-06
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Chiang J;Wang P;Brace CL
通讯作者：
Brace CL
影响因子：
3.2
作者：
Bhattacharya, A;Mahajan, RL
通讯作者：
Mahajan, RL
影响因子：
5.9
作者：
Hoffmann, Ruediger;Rempp, Hansjoerg;Clasen, Stephan
通讯作者：
Clasen, Stephan
DOI：
10.1053/j.tvir.2018.10.005
发表时间：
2019-03-01
影响因子：
1.7
作者：
Lyons, Gray R.;Pua, Bradley B.
通讯作者：
Pua, Bradley B.