A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis.
A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis.
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DOI：
10.1016/j.schres.2010.08.006
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发表时间：
2011-02
影响因子：
4.5
通讯作者：
Cook L
中科院分区：
文献类型：
--
作者：
Penn DL;Uzenoff SR;Perkins D;Mueser KT;Hamer R;Waldheter E;Saade S;Cook L
渐进式康复干预计划（GRIP）是一种新的个体认知行为治疗计划，旨在促进初次精神病发作患者的功能恢复。本研究的目的是评估GRIP干预的可行性和耐受性，并比较GRIP与常规治疗（TAU）在改善特定临床和社会心理结局方面的有效性。46例首发精神病患者随机分为GRIP + TAU组和TAU单独组。主要结果集中于社会和角色功能以及生活质量。次要结局包括精神病症状、抑郁、物质使用、社会支持、对药物的态度、幸福感和住院情况。结果表明GRIP具有良好的耐受性，良好的出勤率和低辍学率证明了这一点，并且受到了良好的接受（基于参与者的积极反馈）。虽然大多数混合模型分析没有统计学意义，但组内变化和效应量的检查表明GRIP在改善功能结局方面优于TAU。这些优点以及GRIP干预所显示的可行性和耐受性表明，该干预值得进一步研究。
The Graduated Recovery Intervention Program (GRIP) is a new individual cognitive-behavioral therapy program designed to facilitate functional recovery in people who have experienced an initial episode of psychosis. The purpose of this study was to evaluate the feasibility and tolerability of the GRIP intervention, and to compare the effectiveness of GRIP versus treatment as usual (TAU) for improving specific clinical and psychosocial outcomes. Forty-six individuals with first episode psychosis were randomized to GRIP + TAU or TAU alone. Primary outcomes focused on social and role functioning, and quality of life. Secondary outcomes included psychotic symptoms, depression, substance use, social support, attitudes toward medications, well-being, and hospitalizations. The results indicate that GRIP was well-tolerated, as evidenced by good attendance and low drop-out rates, and well-received (based on positive feedback from participants). Although the majority of mixed-model analyses were not statistically significant, examination of within-group changes and effect sizes suggest an advantage for GRIP over TAU in improving functional outcomes. These advantages and the fact that the GRIP intervention demonstrated feasibility and tolerability suggest that this intervention is worthy of further investigation.
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