Passive microfluidic pumping using coupled capillary/evaporation effects.
Passive microfluidic pumping using coupled capillary/evaporation effects.
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DOI：
10.1039/b912213c
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发表时间：
2009-12-07
期刊：
影响因子：
6.1
通讯作者：
Dandy DS
中科院分区：
文献类型：
--
作者：
Lynn NS;Dandy DS
通过微流体网络控制泵送流体是芯片实验室应用中普遍存在的关键单元操作。虽然已经有许多研究涉及在芯片实验室设备中创建被动流，但没有一个显示出能够创建时间超过几分钟的暂时稳定流。这里提出了一种被动泵送方法，其中一个大的压力差产生于一个小的，弯曲的半月板沿着出口水库的底角，用于驱动流体通过微流体网络。该系统可以快速达到稳态，并能够在一个多小时的时间内提供精确的体积流量。两步数学模型提供了这些设备中流体和质量传递动力学的准确预测，并通过实验室系统中的粒子跟踪进行了验证。通过控制微通道和出口储层尺寸，可以实现跨越数量级的精确流量。这种流动机制具有应用于许多利用压力驱动流动的微总量分析系统设备的潜力；作为一个说明性的例子，泵送技术被应用于被动产生暂时稳定的化学梯度。
Controlled pumping of fluids through microfluidic networks is a critical unit operation ubiquitous to lab-on-a-chip applications. Although there have been a number of studies involving the creation of passive flows within lab-on-a-chip devices, none has shown the ability to create temporally stable flows for periods longer than several minutes. Here a passive pumping approach is presented in which a large pressure differential arising from a small, curved meniscus situated along the bottom corners of an outlet reservoir serves to drive fluid through a microfluidic network. The system quickly reaches steady-state and is able to provide precise volumetric flow rates for periods lasting over an hour. A two-step mathematical model provides accurate predictions of fluid and mass transport dynamics in these devices, as validated by particle tracking in laboratory systems. Precise flow rates spanning an order of magnitude are accomplished via control of the microchannel and outlet reservoir dimensions. This flow mechanism has the potential to be applied to many micro-total analytical system devices that utilize pressure-driven flow; as an illustrative example, the pumping technique is applied for the passive generation of temporally stable chemical gradients.
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影响因子：
7.4
作者：
Vickers, Jonathan A.;Caulum, Meghan M.;Henry, Charles S.
通讯作者：
Henry, Charles S.
影响因子：
6.1
作者：
Zimmermann, Martin;Schmid, Heinz;Delamarche, Emmanuel
通讯作者：
Delamarche, Emmanuel
影响因子：
6.1
作者：
Cesaro-Tadic, S;Dernick, G;Delamarche, E
通讯作者：
Delamarche, E
影响因子：
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作者：
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通讯作者：
Washburn, EW
影响因子：
56.9
作者：
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通讯作者：
Quake, SR