Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora.
Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora.
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DOI：
10.3389/fphar.2022.814871
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发表时间：
2022
影响因子：
5.6
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Liu X;Wang L;Tan S;Chen Z;Wu B;Wu X
肝硬化是一种肝纤维化形式，由各种肝脏疾病引起的慢性肝炎引起，如病毒性肝炎、酒精性肝损伤、非酒精性脂肪性肝炎、自身免疫性肝病和血吸虫病等寄生虫病。肝纤维化是肝硬化的共同病理基础和先兆。炎症和脂质代谢紊乱是肝纤维化的关键驱动因素。研究已经确定，花生四烯酸途径的某些部分，如其代谢酶和生物活性产物，是炎症的标志，过氧化物酶体增殖激活受体γ (PPARγ)介导的异常调节导致脂质代谢紊乱。然而，尽管目前的研究重点是描述各种慢性肝病的肝纤维化机制，但尚未开发出有效的临床治疗方法。小檗碱（Berberine， BBR）是一种具有抗炎、抗菌、抗癌、抗高脂血症等多种生物活性的异喹啉类生物碱。许多研究也发现BBR通过多种途径减轻肝纤维化。此外，含硝基还原酶的肠道菌群增加了BBR的吸收，并通过与胆汁酸代谢的串扰加强了BBR的吸收。这提高了BBR的口服生物利用度，从而提高了其临床应用价值。BBR显著增加肠道厌氧菌产生丁酸盐，从而放大丁酸盐介导的肝纤维化缓解作用。本文将讨论BBR对肝纤维化和脂质代谢的影响，特别是花生四烯酸的代谢，并强调BBR通过脂质代谢相关途径和肠道菌群相关途径减轻肝纤维化的潜在机制。我们希望这篇综述将为基于BBR的肝硬化治疗和该领域的相关研究提供见解，并鼓励进一步研究提高BBR促进肝脏健康的能力。
Liver cirrhosis is a form of liver fibrosis resulting from chronic hepatitis caused by various liver diseases, such as viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, autoimmune liver disease, and by parasitic diseases such as schistosomiasis. Liver fibrosis is the common pathological base and precursors of cirrhosis. Inflammation and disorders of lipid metabolism are key drivers in liver fibrosis. Studies have determined that parts of the arachidonic acid pathway, such as its metabolic enzymes and biologically active products, are hallmarks of inflammation, and that aberrant peroxisome proliferator-activated receptor gamma (PPARγ)-mediated regulation causes disorders of lipid metabolism. However, despite the ongoing research focus on delineating the mechanisms of liver fibrosis that underpin various chronic liver diseases, effective clinical treatments have yet to be developed. Berberine (BBR) is an isoquinoline alkaloid with multiple biological activities, such as anti-inflammatory, anti-bacterial, anti-cancer, and anti-hyperlipidemic activities. Many studies have also found that BBR acts via multiple pathways to alleviate liver fibrosis. Furthermore, the absorption of BBR is increased by nitroreductase-containing intestinal flora, and is strengthened via crosstalk with bile acid metabolism. This improves the oral bioavailability of BBR, thereby enhancing its clinical utility. The production of butyrate by intestinal anaerobic bacteria is dramatically increased by BBR, thereby amplifying butyrate-mediated alleviation of liver fibrosis. In this review, we discuss the effects of BBR on liver fibrosis and lipid metabolism, particularly the metabolism of arachidonic acid, and highlight the potential mechanisms by which BBR relieves liver fibrosis through lipid metabolism related and intestinal flora related pathways. We hope that this review will provide insights on the BBR-based treatment of liver cirrhosis and related research in this area, and we encourage further studies that increase the ability of BBR to enhance liver health.
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影响因子：
4.1
作者：
Caliceti, Cristiana;Franco, Placido;Cicero, Arrigo F. G.
通讯作者：
Cicero, Arrigo F. G.
Warburg效应决定了丁酸酯介导的组蛋白乙酰化和细胞增殖的机制。
影响因子：
16
作者：
Donohoe, Dallas R.;Collins, Leonard B.;Wali, Aminah;Bigler, Rebecca;Sun, Wei;Bultman, Scott J.
通讯作者：
Bultman, Scott J.
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
3.6
作者：
Barbagallo, Carlo M;Cefalo, Angelo Baldassare;Averna, Maurizio R
通讯作者：
Averna, Maurizio R
影响因子：
4.5
作者：
Domitrovic, Robert;Jakovac, Hrvoje;Blagojevic, Gordana
通讯作者：
Blagojevic, Gordana