Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.
Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.
复制标题
Roux-en-Y胃绕道手术预防胰腺腺泡细胞癌
DOI：
10.1038/s41467-018-06571-w
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发表时间：
2018-10-10
影响因子：
16.6
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
He R;Yin Y;Yin W;Li Y;Zhao J;Zhang W
Roux-en-Y胃旁路手术（RYGB）可预防雄性和雌性Ngn3-Tsc1−/−小鼠胰腺细胞腺泡癌（ACC）的发生。Ngn3定向Cre缺失Tsc1基因可诱导胰腺ACC的发生。假手术转基因小鼠300日龄肿瘤发生率为96.7±3.35%，存活率为67.0±1.4%。肝转移率为69.7±9.7%，肾转移率为44.3±8.01%。所有在16周龄进行RYGB的动物在300日龄时都能存活。RYGB显著减弱胰腺ACC中mTORC1信号的激活和肿瘤抑制基因p21、p27和p53的抑制。我们的研究表明，减肥手术可能通过抑制胰腺mTORC1信号传导来限制胰腺ACC的发生和生长。RYGB显示了对代谢功能障碍和器官癌的干预前景。肥胖和糖尿病患者患胰腺癌的风险增加。在这篇论文中，作者表明Roux-en-Y胃旁路手术（RYGB）在小鼠模型中降低了胰腺癌的影响；这种作用似乎独立于体重减轻或高血糖降低，表明mTOR通路的参与。
Roux-en-Y Gastric Bypass Surgery (RYGB) prevents the occurrence of pancreatic cell acinar carcinoma (ACC) in male and female Ngn3-Tsc1−/− mice. Ngn3 directed Cre deletion of Tsc1 gene induced the development of pancreatic ACC. The transgenic mice with sham surgery demonstrated a cancer incidence of 96.7 ± 3.35% and survival rate of 67.0 ± 1.4% at the age of 300 days. Metastasis to liver and kidney was observed in 69.7 ± 9.7% and 44.3 ± 8.01% of these animals, respectively. All animals with RYGB performed at the age of 16 weeks survived free of pancreatic ACC up to the age of 300 days. RYGB significantly attenuated the activation of mTORC1 signaling and inhibition of tumor suppressor genes: p21, p27, and p53 in pancreatic ACC. Our studies demonstrate that bariatric surgery may limit the occurrence and growth of pancreatic ACC through the suppression of mTORC1 signaling in pancreas. RYGB shows promise for intervention of both metabolic dysfunction and organ cancer. Pancreatic cancer risk increases in obese and diabetic people. In this manuscript, the authors show that Roux-en-Y gastric bypass surgery (RYGB) decreases the impact of pancreatic cancer in a mouse model; this effect seems independent of weight loss or decreased hyperglycemia pointing to an involvement of mTOR pathway.
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影响因子：
7.7
作者：
Shah M;Law JH;Micheletto F;Sathananthan M;Dalla Man C;Cobelli C;Rizza RA;Camilleri M;Zinsmeister AR;Vella A
通讯作者：
Vella A
雷帕霉素复合物 1 信号传导的武田 G 蛋白偶联受体 5 机制靶点有助于 Roux-en-Y 胃旁路手术后胰高血糖素样肽 1 产量的增加
影响因子：
11.1
作者：
Zhai, Hening;Li, Zhi;Xu, Geyang
通讯作者：
Xu, Geyang
影响因子：
3.1
作者：
Debs, Tarek;Petrucciani, Niccolo;Gugenheim, Jean
通讯作者：
Gugenheim, Jean
胰腺神经内分泌肿瘤中经常改变DAXX/ATRX，MEN1和MTOR途径基因。
DOI：
10.1126/science.1200609
发表时间：
2011-03-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiao Y;Shi C;Edil BH;de Wilde RF;Klimstra DS;Maitra A;Schulick RD;Tang LH;Wolfgang CL;Choti MA;Velculescu VE;Diaz LA Jr;Vogelstein B;Kinzler KW;Hruban RH;Papadopoulos N
通讯作者：
Papadopoulos N
影响因子：
254.7
作者：
Jemal, A;Tiwari, RC;Thun, MJ
通讯作者：
Thun, MJ