Reduced memory-related ongoing oscillatory activity in healthy older adults
Reduced memory-related ongoing oscillatory activity in healthy older adults
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健康老年人中与记忆相关的持续振荡活动减少
DOI：
10.1016/j.neurobiolaging.2019.03.012
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发表时间：
2019
影响因子：
4.2
通讯作者：
Stephanie M. Shields
中科院分区：
文献类型：
--
作者：
Schneider;Stephanie M. Shields
情景记忆中的与记忆相关的损伤与编码诱导的神经活动的改变有关。在年轻个体中，甚至刺激前活动也被证明会影响即将到来的刺激的编码，持续的θ和β振荡可以预测随后的识别。本研究调查了这些与记忆相关的持续振荡是否也受到衰老的影响。在EEG实验中，健康的老年人和年轻人进行编码任务，随后对图片和文字刺激进行识别测试。与老年人相比，年轻参与者组在刺激前和刺激后的较低频率范围（范围从3到17 Hz）内表现出增加的振荡活动。只有在年轻的参与者中，编码过程中持续的β功率与两种刺激类别的后期记忆有关，而在老年参与者中，这种影响减弱了。有趣的是，识别能力并没有出现与年龄相关的普遍下降。这些结果表明，持续的低β振荡可能构成认知老化的功能指标，甚至在行为表现明显下降之前就显示出来，这可能是神经调节干预的潜在目标。
Age-related impairments in episodic memory have been linked to alterations in encoding-induced neural activity. In young individuals, even prestimulus activity has been shown to influence the encoding of an upcoming stimulus, with ongoing theta and beta oscillations being predictive of subsequent recognition. The present study investigated if these memory-related ongoing oscillations are also affected by aging. In an EEG experiment, healthy older and young individuals performed an encoding task with a subsequent recognition test on picture and word stimuli. The group of younger participants showed an increased oscillatory activity in the lower frequency range (ranging from 3 to 17 Hz) in the pre- and post-stimulus period compared with the older adults. Only in young participants, ongoing beta power during encoding was related to later memory in both stimulus categories, whereas in older participants, this effect was diminished. Interestingly, there was no general age-related decrease in recognition performance. These results indicate that ongoing low beta oscillations might constitute a functional indicator of cognitive aging that reveals itself even before a strong decline in behavioral performance is noticeable, and that could be a potential target for neuromodulatory interventions.
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影响因子：
3
作者：
Enriquez-Geppert S;Huster RJ;Figge C;Herrmann CS
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
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通讯作者：
Keiichi Kitajo
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影响因子：
--
作者：
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通讯作者：
P. Miller