Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference.
Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference.
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DOI：
10.3389/fnbeh.2022.956102
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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青春期是以大脑成熟和社交活动变化为特征的发育期。社会环境的变化会影响社会行为。对社交事件的记忆，包括对熟悉的个人的记忆，需要在编码过程中进行社交参与。因此，成人和青少年社交曲目的现有差异以及环境驱动的社会行为变化可能会影响与社会认可相关的新的伴侣偏好。杏仁核的几个亚区对社会环境很敏感，可以影响社会行为，这对新奇偏好至关重要。杏仁核神经元投射到隔区和伏隔核(NAC)，这两个区域与社会参与有关。在这里，我们调查了社会环境如何在社会编码过程中影响特定年龄的社会行为，以及随后对伴侣偏好的影响。然后，我们检查了伴随这些变化的杏仁核-隔区和-NAC环路的变化。短暂的隔离可以驱动成年人和青少年的社交行为，并在编码过程中被用来增加社交参与度。我们发现，短暂的隔离促进了青少年和成年人的社交互动，随着时间的推移，分析表明，所有群体的伴侣歧视都是完好无损的，但在孤立和非孤立的群体中，偏好发生了变化。我们发现，与其他杏仁核亚区相比，这种隔离优先增加成人杏仁核(BA)的活性，但在青少年中，即使考虑到条件(未隔离、隔离)，杏仁核亚区域之间的活动也是相似的。此外，在成人和青少年中，我们发现隔离导致BA-NAC和BA-间隔回路的增加。综上所述，这些结果为杏仁核亚区域内神经元群体及其对社会环境敏感的投射的变化提供了证据，社会环境可能会影响发育过程中短暂孤立群体内的社会互动模式。
Adolescence is a developmental period characterized by brain maturation and changes in social engagement. Changes in the social environment influence social behaviors. Memories of social events, including remembering familiar individuals, require social engagement during encoding. Therefore, existing differences in adult and adolescent social repertoires and environmentally-driven changes in social behavior may impact novel partner preference, associated with social recognition. Several amygdala subregions are sensitive to the social environment and can influence social behavior, which is crucial for novelty preference. Amygdala neurons project to the septum and nucleus accumbens (NAc), which are linked to social engagement. Here, we investigated how the social environment impacts age-specific social behaviors during social encoding and its subsequent impact on partner preference. We then examined changes in amygdala-septal and -NAc circuits that accompany these changes. Brief isolation can drive social behavior in both adults and adolescents and was used to increase social engagement during encoding. We found that brief isolation facilitates social interaction in adolescents and adults, and analysis across time revealed that partner discrimination was intact in all groups, but there was a shift in preference within isolated and non-isolated groups. We found that this same isolation preferentially increases basal amygdala (BA) activity relative to other amygdala subregions in adults, but activity among amygdala subregions was similar in adolescents, even when considering conditions (no isolation, isolation). Further, we identify isolation-driven increases in BA-NAc and BA-septal circuits in both adults and adolescents. Together, these results provide evidence for changes in neuronal populations within amygdala subregions and their projections that are sensitive to the social environment that may influence the pattern of social interaction within briefly isolated groups during development.
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影响因子：
4.6
作者：
Fernandez-Theoduloz, Gabriela;Paz, Valentina;Gradin, Victoria B.
通讯作者：
Gradin, Victoria B.
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Bhatnagar, Seema
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作者：
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通讯作者：
Helmstetter, Fred J.