An application of univariate and multivariate approaches in FMRI to quantifying the hemispheric lateralization of acoustic and linguistic processes.
An application of univariate and multivariate approaches in FMRI to quantifying the hemispheric lateralization of acoustic and linguistic processes.
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DOI：
10.1162/jocn_a_00161
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发表时间：
2012-03
影响因子：
3.2
通讯作者：
Scott SK
中科院分区：
文献类型：
--
作者：
McGettigan C;Evans S;Rosen S;Agnew ZK;Shah P;Scott SK
神经过程的半球侧化问题是一个与认知神经科学的一系列分支学科相关的问题。语言通常被认为在人脑中处于偏侧化状态，但关于其根本原因的争论由来已久。我们通过fMRI来解决这个问题，通过识别神经对语音中幅度和光谱调制的反应，以及这些反应如何与语音可理解性相互作用，来检验之前关于语音感知中声学和语言过程中大脑半球不对称的说法。我们对数据进行了单变量和多变量分析，这使我们能够识别处理这些声学和语言因素所涉及的网络，并测试任何明显的半球不对称的重要性。我们展示了在缺乏可理解性的情况下，双侧颞叶上皮质对语音衍生的声学调制的反应。然而，在幅度调制和频谱调制条件的对比中，只有在可理解性上有所不同(其中一个是部分可理解的，另一个是不可理解的)，我们显示了在脑岛、额叶下部皮质和颞叶上沟的左侧主导激活模式。重要的是，多变量模式分析(MVPA)显示，只有在可理解语音的处理上，左右半球才有显著差异。这一结果表明，左脑在语言加工中的优势并不是由于低水平的语音来源的声学因素造成的，MVPA提供了一种在加工过程中对大脑半球不对称进行无偏测试的方法。
The question of hemispheric lateralization of neural processes is one that is pertinent to a range of subdisciplines of cognitive neuroscience. Language is often assumed to be left lateralized in the human brain, but there has been a long running debate about the underlying reasons for this. We addressed this problem with fMRI by identifying the neural responses to amplitude and spectral modulations in speech, and how these interact with speech intelligibility, to test previous claims for hemispheric asymmetries in acoustic and linguistic processes in speech perception. We used both univariate and multivariate analyses of the data, which enabled us to both identify the networks involved in processing these acoustic and linguistic factors, and to test the significance of any apparent hemispheric asymmetries. We demonstrate bilateral activation of superior temporal cortex in response to speech-derived acoustic modulations in the absence of intelligibility. However, in a contrast of amplitude- and spectrally-modulated conditions that differed only in their intelligibility (where one was partially intelligible and the other unintelligible), we show a left-dominant pattern of activation in insula, inferior frontal cortex and superior temporal sulcus. Crucially, multivariate pattern analysis (MVPA) showed that there were significant differences between the left and the right hemispheres only in the processing of intelligible speech. This result shows that the left hemisphere dominance in linguistic processing does not arise due to low-level, speech-derived acoustic factors, and that MVPA provides a method for unbiased testing of hemispheric asymmetries in processing.
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影响因子：
5.3
作者：
Eisner, Frank;McGettigan, Carolyn;Scott, Sophie K.
通讯作者：
Scott, Sophie K.
影响因子：
5.3
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5.7
作者：
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影响因子：
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影响因子：
5.3
作者：
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通讯作者：
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