Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.
Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.
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DOI：
10.1007/s00421-022-05022-1
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发表时间：
2022-11
影响因子：
3
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中科院分区：
文献类型：
--
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他汀类药物可能通过多效性机制改善脑血流量。本研究的目的是评估他汀类药物对有血脂异常和痴呆家族史的老年人脑血管变量的影响。此外，由于他汀类药物试验中普遍存在的偏见，我们探讨了他汀类药物使用与性别之间的相互作用。采用经颅多普勒超声检测大脑中动脉血流速度（MCAv）。连续仰卧休息记录持续8分钟。分析中包括他汀类药物（n = 100）或非他汀类药物使用者（n = 112）。他汀类药物使用者的MCAv和脑血管传导性显著更高（p = 0.047; p = 0.04），脉动指数（PI）显著更低（p <0.01）。他汀类药物的使用和性别之间的相互作用影响PI（p = 0.02）;女性他汀类药物使用者的脑血管阻力显着低于其他三组。在这项横断面分析中，他汀类药物的使用与老年痴呆症患者的脑血管变量呈正相关。女性他汀类药物使用者的静息MCAv和脑血管传导性显著高于女性非他汀类药物使用者。他汀类药物使用的最大贡献是与脑血管阻力降低相关。鉴于脑血管失调是阿尔茨海默病和相关痴呆病理学的最早变化之一，用他汀类药物靶向脑血管系统可能是一种有前途的预防策略。
It is plausible that statins could improve cerebral blood flow through pleiotropic mechanisms. The purpose of this investigation was to assess the contribution of statins to cerebrovascular variables in older adults with dyslipidemia and familial history of dementia. Furthermore, we explored the interaction between statin use and sex due to prevalent bias in statin trials. Middle cerebral artery blood flow velocity (MCAv) was measured using transcranial Doppler ultrasound. Continuous supine rest recordings lasted 8 min. Participants included in analyses were statin (n = 100) or non-statin users (n = 112). MCAv and cerebrovascular conductance were significantly higher in statin users (p = 0.047; p = 0.04), and pulsatility index (PI) was significantly lower in statin users (p < 0.01). An interaction effect between statin use and sex was present for PI (p = 0.02); female statin users had significantly lower cerebrovascular resistance than the other three groups. In this cross-sectional analysis, statin use was positively associated with cerebrovascular variables in older adults at risk for dementia. Female statin users had significantly higher resting MCAv and cerebrovascular conductance than female non-statin users. The greatest contribution of statin use was the association with reduced cerebrovascular resistance. Given that cerebrovascular dysregulation is one of the earliest changes in Alzheimer’s disease and related dementia pathology, targeting the cerebrovasculature with statins may be a promising prevention strategy.
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