The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia.
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia.
复制标题
DOI：
10.1007/s00401-010-0718-6
复制
发表时间：
2010-09
影响因子：
12.7
通讯作者：
Iadecola C
中科院分区：
文献类型：
--
作者：
Iadecola C
越来越多的证据表明，脑血管功能障碍不仅在认知障碍的血管原因中起作用，而且在阿尔茨海默病(AD)中也起作用。血管危险因素和阿尔茨海默病会损害脑血管及其相关细胞(神经血管单位)的结构和功能，这种影响是由血管氧化应激和炎症介导的。神经血管单位的损伤改变了大脑的血流调节，耗尽了血管储备，破坏了血脑屏障，降低了大脑的修复潜力，从而放大了因偶发缺血和共存的神经变性而造成的脑功能障碍和损害。临床病理研究支持这样的观点，即血管病变通过降低认知障碍的阈值和加快痴呆的速度来加剧AD病理的有害影响。在缺乏基于机制的方法来抵消认知功能障碍的情况下，针对血管风险因素和改善脑血管健康提供了机会来缓解这一人类最致残的疾病之一的影响。
There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer’s disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood–brain barrier, and reduces the brain’s repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions.
登录
查看更多内容
影响因子：
168.9
作者：
Esiri, MM;Nagy, Z;Smith, AD
通讯作者：
Smith, AD
影响因子：
5.3
作者：
Arai, Ken;Lo, Eng H.
通讯作者：
Lo, Eng H.
影响因子：
82.9
作者：
Deane, R;Yan, SD;Zlokovic, B
通讯作者：
Zlokovic, B
影响因子：
2
作者：
Bateman, Grant A.;Levi, Christopher R.;Lovett, Elizabeth C.
通讯作者：
Lovett, Elizabeth C.
DOI：
10.1073/pnas.0608251104
发表时间：
2007-01-16
影响因子：
11.1
作者：
Chow, Nienwen;Bell, Robert D.;Zlokovic, Berislav V.
通讯作者：
Zlokovic, Berislav V.