Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium
Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium
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腺苷和振荡 cAMP 信号之间的相互作用调节盘基网柄菌的大小和模式
DOI：
10.1016/0092-8674(86)90545-3
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发表时间：
1986
期刊：
影响因子：
64.5
通讯作者：
Mei Wang
中科院分区：
文献类型：
--
作者：
P. Schaap;Mei Wang
我们提出的证据表明，在盘基骨柱的多细胞结构中，通过顶端附近的CAMP水解产生腺苷可以防止尖端附近的竞争尖端的产生和前孢子细胞的分化，从而建立一个“前柄”区域。我们证明腺苷以与CAMP相反的方式影响鼻涕虫的免疫孢子前特异性染色模式：CAMP诱导孢子前抗原增加；腺苷诱导减少。当从鼻涕虫中去除内源性腺苷时，孢子前液泡在整个柄前区域合成。腺苷以明显的竞争性方式抑制CAMP诱导的孢子前分化。还发现腺苷特异性地增加了由一个尖端控制的组织的数量，可能是通过抑制竞争振荡的产生。从鼻涕虫中去除内源性腺苷导致尖端优势降低。
We present evidence for the hypothesis that in multicellular structures of Dictyostelium, production of adenosine by hydrolysis of CAMP near the tip region prevents both generation of competing tips and differentiation of prespore cells near the tip, and thus establishes a “prestalk” region. We demonstrate that adenosine affects the immunological prespore specific staining pattern in slugs in a manner opposite to CAMP: cAMP induces an increase of prespore antigen; adenosine induces a decrease. When endogenous adenosine is removed from slugs, prespore vacuoles are synthesized throughout the prestalk region. Adenosine was found to inhibit the induction of prespore differentiation by CAMP in an apparently competitive manner. It was also found that adenosine specifically increased the amount of tissue controlled by one tip, probably by inhibiting generation of competing oscillators. Removing endogenous adenosine from slugs resulted in a decrease of tip dominance.
盘基网柄菌的大小调节。
DOI：
--
发表时间：
1982
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
Kopachik,W
通讯作者：
Kopachik,W
使用单克隆抗体检测盘基网柄菌和粘液盘基网柄菌的前孢子细胞之间的抗原差异。
影响因子：
3.7
作者：
Gregg,JH;Krefft,M;Haas-Kraus,A;Williams,KL
通讯作者：
Williams,KL