Growth hormone neurosecretory dysfunction. A treatable cause of short stature.
Growth hormone neurosecretory dysfunction. A treatable cause of short stature.
复制标题
生长激素神经分泌功能障碍。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
B. Bercu,
中科院分区：
文献类型：
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作者：
B. Spiliotis;G. August;W. Hung;W. Sonis;W. Mendelson;B. Bercu,
对矮小儿童亚组的脉动生长激素 (GH) 分泌进行评估，以确定他们是否存在 GH 分泌异常，并将这些结果与正常儿童和 GH 缺乏儿童的结果进行比较。该亚组儿童被定义为患有 GH 神经分泌功能障碍，并符合以下标准：身高低于第一个百分位数；生长速度，4 厘米/年或更低；骨龄，比实际年龄晚两年或更多年，激发 GH 测试结果正常（峰值，大于或等于 10 ng/mL），生长调节素 C 水平低，以及异常的 24 小时 GH 分泌模式。与对照组相比，患有 GH 神经分泌功能障碍的儿童和 GH 缺乏的患者在 24 小时内与 GH 总分泌相关的参数均显着下降。与缺乏 GH 的儿童一样，在治疗的第一年，使用外源性人 GH 替代治疗后，患有 GH 神经分泌功能障碍的儿童的生长速度增加了一倍多。作为对脉冲式 GH 分泌的这些详细研究的结果，我们认为存在一系列 GH 分泌异常，从 GH 分泌的绝对缺乏到间歇性不规则。
Pulsatile growth hormone (GH) secretion was assessed in a subgroup of short children to determine whether they had GH secretory abnormalities, and these results were compared with those of normal and GH-deficient children. This subgroup of children was defined as having GH neurosecretory dysfunction and met the following criteria: height, less than first percentile; growth velocity, 4 cm/yr or less; bone age, two or more years behind chronological age, normal findings from provocative GH tests (peak, greater than or equal to 10 ng/mL), low somatomedin-C level, and abnormal 24-hour GH secretory patterns. When compared with controls, both children with GH neurosecretory dysfunction and GH-deficient patients had a significant decrease in parameters relating to the total GH secretion during the 24-hour period. As with GH-deficient children, the group with GH neurosecretory dysfunction more than doubled their growth velocity after replacement therapy with exogenous human GH during the first year of treatment. As a result of these detailed studies on pulsatile GH secretion, we suggest that there is a spectrum of GH secretory abnormalities from absolute deficiency to an intermittent irregularity in GH secretion.
侏儒儿童的生长和生长调节素-C 对生长激素的反应。
DOI：
10.1016/s0022-3476(81)80008-x
发表时间：
1981
期刊：
The Journal of pediatrics
影响因子：
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作者：
Hayek,A;Peake,GT
通讯作者：
Peake,GT