Replication of the association of a MET variant with autism in a Chinese Han population.
Replication of the association of a MET variant with autism in a Chinese Han population.
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DOI：
10.1371/journal.pone.0027428
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Zhou X;Xu Y;Wang J;Zhou H;Liu X;Ayub Q;Wang X;Tyler-Smith C;Wu L;Xue Y
Autism is a common, severe and highly heritable neurodevelopmental disorder in children, affecting up to 100 children per 10,000. The MET gene has been regarded as a promising candidate gene for this disorder because it is located within a replicated linkage interval, is involved in pathways affecting the development of the cerebral cortex and cerebellum in ways relevant to autism patients, and has shown significant association signals in previous studies. Here, we present new ASD patient and control samples from Heilongjiang, China and use them in a case-control and family-based replication study of two MET variants. One SNP, rs38845, was successfully replicated in a case-control association study, but failed to replicate in a family-based study, possibly due to small sample size. The other SNP, rs1858830, failed to replicate in both case-control and family-based studies. This is the first attempt to replicate associations in Chinese autism samples, and our result provides evidence that MET variants may be relevant to autism susceptibility in the Chinese Han population.
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