Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing.
Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing.
复制标题
成纤维细胞：糖尿病难治性伤口愈合中的免疫调节因子。
DOI：
10.3389/fimmu.2022.918223
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
Nie, Xuqiang
中科院分区：
文献类型：
--
作者：
Liu, Ye;Liu, Yiqiu;He, Wenjie;Mu, Xingrui;Wu, Xingqian;Deng, Junyu;Nie, Xuqiang
Diabetes is a systemic disease in which patients with diabetes may develop peripheral neuropathy of the lower extremities and peripheral vascular disease due to long-term continuous exposure to high glucose. Delayed wound healing in diabetes is one of the major complications of diabetes. Slow wound healing in diabetic patients is associated with high glucose toxicity. When the condition deteriorates, the patient needs to be amputated, which seriously affects the quality of life and even endangers the life of the patient. In general, the delayed healing of diabetes wound is due to the lack of chemokines, abnormal inflammatory response, lack of angiogenesis and epithelial formation, and fibroblast dysfunction. The incidence of several chronic debilitating conditions is increasing in patients with diabetes, such as chronic renal insufficiency, heart failure, and hepatic insufficiency. Fibrosis is an inappropriate deposition of extracellular matrix (ECM) proteins. It is common in diabetic patients causing organ dysfunction. The fibrotic mechanism of diabetic fibroblasts may involve direct activation of permanent fibroblasts. It may also involve the degeneration of fibers after hyperglycemia stimulates immune cells, vascular cells, or organ-specific parenchymal cells. Numerous studies confirm that fibroblasts play an essential role in treating diabetes and its complications. The primary function of fibroblasts in wound healing is to construct and reshape the ECM. Nowadays, with the widespread use of single-cell RNA sequencing (scRNA-seq), an increasing number of studies have found that fibroblasts have become the critical immune sentinel cells, which can detect not only the activation and regulation of immune response but also the molecular pattern related to the injury. By exploring the heterogeneity and functional changes of fibroblasts in diabetes, the manuscript discusses that fibroblasts may be used as immunomodulatory factors in refractory diabetic wound healing, providing new ideas for the treatment of refractory diabetic wound healing.
登录
查看更多内容
影响因子：
3.4
作者：
Ai J;Liu Y;Sun JH
通讯作者：
Sun JH
影响因子：
3.7
作者：
Abu-Ashour W;Twells LK;Valcour JE;Gamble JM
通讯作者：
Gamble JM
心脏成纤维细胞生理学和病理学
影响因子：
5.8
作者：
Dostal, David;Glaser, Shannon;Baudino, Troy A.
通讯作者：
Baudino, Troy A.
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--