Thyrotoxic periodic paralysis: clinical challenges.
Thyrotoxic periodic paralysis: clinical challenges.
复制标题
甲状腺毒性周期性麻痹：临床挑战。
DOI：
10.1155/2014/649502
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发表时间：
2014
影响因子：
2.1
通讯作者：
Thimmappa D
中科院分区：
文献类型：
--
作者：
Vijayakumar A;Ashwath G;Thimmappa D
Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipitate an attack of TPP. Evidence is building up showing role of genetic mutations in Kir2.6 channel in the pathogenesis of TPP. Loss of function of Kir2.6 together with increased activity of Na+/K+ ATPase may trigger a positive feed-forward cycle of hypokalemia. Biochemical hyperthyroidism with normal urinary potassium excretion and ECG changes are characteristic of TPP. Treatment with low-dose potassium supplements and nonselective beta-blockers should be initiated upon diagnosis, and the serum potassium level should be frequently monitored to prevent rebound hyperkalemia.
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影响因子：
2
作者：
Akar, S;Comlekci, A;Akkoc, N
通讯作者：
Akkoc, N
影响因子：
--
作者：
CHAN, A;SHINDE, R;SWAMINATHAN, R
通讯作者：
SWAMINATHAN, R
影响因子：
3.2
作者：
CHAN, A;SHINDE, R;SWAMINATHAN, R
通讯作者：
SWAMINATHAN, R
影响因子：
3.1
作者：
Hsu, FS;Tsai, WS;Lin, SH
通讯作者：
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影响因子：
3.1
作者：
Liu, YC;Tsai, WS;Lin, SH
通讯作者：
Lin, SH