Altered neurometabolite development in HIV-infected children
Altered neurometabolite development in HIV-infected children
复制标题
HIV感染儿童神经代谢物发育的改变
作者：
M. Keller;T. Venkatraman;A. Thomas;A. Deveikis;C. LoPresti;J. Hayes;Nancy Berman;I. Walot;S. Padilla;J. Johnston;T. Ernst;Linda Chang
Background: HIV-infected children have abnormal cerebral metabolites, measured by proton MR spectroscopy (1H-MRS), but how these abnormalities relate to brain function is unclear. Methods: Metabolite concentrations in five brain regions of 20 HIV-infected and 13 control children were measured, and these findings were correlated with age, log10 plasma viral load, CD4 count, and neuropsychological scores. Results: Compared with control subjects, HIV patients had decreased choline concentration [Cho] in left frontal white matter (LFW) (−12%; p = 0.04); those with high viral load (>5,000 HIV RNA copies/mL) had decreased right basal ganglia (RBG) [Cho] (−15%; p = 0.005), and [Cr] (−13%; p = 0.02). Patients with high viral load also had higher [Cho] in the midfrontal gray matter (MFG) (+25%; p = 0.002) and lower myo-inositol [Ins] in the RBG (−18%; p = 0.04) than patients with low HIV viral load. N-Acetyl aspartate concentration ([NAA]) correlated with age in right frontal white matter (RFW) (r = 0.59, p = 0.04), LFW (r = 0.66, p = 0.02), and right hippocampus (RHIP) (r = 0.69, p = 0.02) only in control subjects. In contrast, [Ins] correlated with age in both RFW and LFW (r = 0.71, p = 0.0006; r = 0.65, p = 0.006) only in the HIV patients. Log10 plasma viral load correlated positively with [Ins] in RFW (r = 0.54, p = 0.02) and [Cho] in MFG (r = 0.49, p = 0.04). Compared with control subjects, HIV patients had poorer spatial memory (p = 0.045) and delayed spatial memory correlated with [Cho] in RHIP (r = 0.68, p = 0.02). Conclusions: These data suggest that normal brain development may be affected in children infected with HIV at birth, particularly evidenced by the lack of age-related increases in the neuronal marker [NAA]. Early, aggressive treatment of infants with HIV before development of encephalopathy is warranted.
儿童艾滋病脑病中的脑乳酸和 N-乙酰天冬氨酸。
DOI：
--
发表时间：
1998
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Pavlakis,SG;Lu,D;Frank,Y;Wiznia,A;Eidelberg,D;Barnett,T;Hyman,RA
通讯作者：
Hyman,RA
小儿艾滋病的中枢神经系统。
影响因子：
5.2
作者：
Kozlowski,PB;Sher,JH;Rao,C;Anzil,PA;Wrzolek,MA;Sharer,L;Cho,ES;Dickson,DW;Weidenheim,KM;Llena,JF
通讯作者：
Llena,JF