Cell-cell contact and signaling in the muscle stem cell niche.

Cell-cell contact and signaling in the muscle stem cell niche.
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DOI:
10.1016/j.ceb.2021.06.003
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发表时间:
2021-12
影响因子:
7.5
通讯作者:
Krauss RS
Krauss RS
中科院分区:
生物学2区
文献类型:
--
作者:
Kann AP;Hung M;Krauss RS

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肌肉干细胞(也称为卫星细胞或SCs)在体内平衡和再生过程中依赖于其局部生态位的调节信号。虽然许多细胞类型通过分泌因子间接交流,但这里我们关注的是sc与其相邻细胞之间直接联系的重要性。在静息期间,SCs位于基底层,并从邻近的骨骼肌纤维接收促静信号。损伤后,生态位的组成发生了实质性的变化,使新的接触形成,介导增殖、自我更新和分化。在这篇综述中,我们总结了了解卫星细胞生态位内细胞-细胞接触的最新工作,并强调了未来研究的开放性问题。
Muscle stem cells (also called satellite cells, or SCs) rely on their local niche for regulatory signals during both homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus on the significance of direct contact between SCs and their neighbors. During quiescence, SCs reside under a basal lamina and receive quiescence-promoting signals from their adjacent skeletal myofibers. Upon injury, the composition of the niche changes substantially, enabling the formation of new contacts that mediate proliferation, self-renewal, and differentiation. In this review, we summarize the latest work in understanding cell-cell contact within the satellite cell niche and highlight areas of open questions for future studies.
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