Cell-cell contact and signaling in the muscle stem cell niche.
Cell-cell contact and signaling in the muscle stem cell niche.
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DOI:
10.1016/j.ceb.2021.06.003
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发表时间:
2021-12
影响因子:
7.5
通讯作者:
Krauss RS
中科院分区:
文献类型:
--
作者:
Kann AP;Hung M;Krauss RS
Muscle stem cells (also called satellite cells, or SCs) rely on their local niche for regulatory signals during both homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus on the significance of direct contact between SCs and their neighbors. During quiescence, SCs reside under a basal lamina and receive quiescence-promoting signals from their adjacent skeletal myofibers. Upon injury, the composition of the niche changes substantially, enabling the formation of new contacts that mediate proliferation, self-renewal, and differentiation. In this review, we summarize the latest work in understanding cell-cell contact within the satellite cell niche and highlight areas of open questions for future studies.
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DOI:
10.1126/science.1191035
发表时间:
2010-08-27
期刊:
Science (New York, N.Y.)
影响因子:
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通讯作者:
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