Eph receptor signaling and ephrins.
Eph receptor signaling and ephrins.
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DOI：
10.1101/cshperspect.a009159
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发表时间：
2013-09-01
影响因子：
7.2
通讯作者：
Pasquale EB
中科院分区：
文献类型：
--
作者：
Lisabeth EM;Falivelli G;Pasquale EB
Eph受体是受体酪氨酸激酶（RTK）家族中最大的一类。与其他RTK一样，它们通过配体诱导其激酶结构域的激活，将信号从细胞外传递到细胞内。然而，Eph受体也有其独特的特征。它们通常不结合可溶性配体，而是通过与相邻细胞上的膜表面相关配体——ephrin相互作用，介导依赖接触的细胞间通讯。Eph受体 - ephrin复合物发出双向信号，影响表达受体和表达ephrin的细胞。有趣的是，ephrin也能减弱同一细胞中共表达的Eph受体的信号传导。此外，Eph受体可以不依赖ephrin结合和激酶活性来调节细胞行为。Eph/ephrin系统调控许多发育过程和成年组织内稳态。其异常功能与包括癌症在内的多种疾病有关。因此，Eph受体是有前景的治疗靶点。然而，需要更多的研究来更好地理解其复杂生物学中许多仍然神秘的方面。
The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. However, the Eph receptors also have distinctive features. Instead of binding soluble ligands, they generally mediate contact-dependent cell-cell communication by interacting with surface-associated ligands – the ephrins – on neighboring cells. Eph receptor-ephrin complexes emanate bidirectional signals that affect both receptor- and ephrin-expressing cells. Intriguingly, ephrins can also attenuate signaling by Eph receptors co-expressed in the same cell. Additionally, Eph receptors can modulate cell behavior independently of ephrin binding and kinase activity. The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. Its abnormal function has been implicated in various diseases, including cancer. Thus, Eph receptors represent promising therapeutic targets. However, more research is needed to better understand the many aspects of their complex biology that remain mysterious.
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影响因子：
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