Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk.
Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk.
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DOI：
10.1002/ijc.24406
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发表时间：
2009-08-01
影响因子：
6.4
通讯作者：
Helzlsouer KJ
中科院分区：
文献类型：
--
作者：
McSorley MA;Alberg AJ;Allen DS;Allen NE;Brinton LA;Dorgan JF;Kaaks R;Rinaldi S;Helzlsouer KJ
促性腺激素已被指控在卵巢癌的发生，但直接的证据一直是有限的和不一致的。本研究的目的是确定诊断前促卵泡激素（FSH）水平与浸润性上皮性卵巢癌后续发展之间的关系。使用来自三个队列的病例和对照进行巢式病例对照研究：华盛顿县的CLUE I和CLUE II，MD和英国的根西岛研究。总共有67例侵袭性上皮性卵巢癌病例在年龄、绝经状态、自末次月经以来的时间、当前激素使用和其他相关因素方面与一到两个对照组相匹配。根据对照组的分布情况，将FSH浓度分为低、中或高三分之一。使用条件Logistic回归估计FSH浓度增加三分之一时的比值比（OR）。分析结果显示，卵巢癌风险随着FSH浓度的升高而降低（p趋势=0.005）。与FSH浓度最低的三分之一相比，中间和最高三分之一的比值比分别为0.45（95%置信区间（CI）0.20- 1.00）和0.26（95% CI 0.10-0.70）。在排除了随访5年内诊断的病例后，相关性仍然存在。总之，在循环FSH浓度较高的女性中观察到浸润性上皮性卵巢癌的后续风险降低。这些发现与FSH作为卵巢癌发生的危险因素的假设作用相矛盾。
Gonadotropins have been indicted in ovarian carcinogenesis but direct evidence has been limited and inconsistent. The aim of this study was to determine the association between pre-diagnostic levels of follicle stimulating hormone (FSH) and subsequent development of invasive epithelial ovarian cancer. A nested case-control study was conducted using cases and controls drawn from three cohorts: CLUE I and CLUE II of Washington County, MD, and the Island of Guernsey Study, UK. In total, 67 incident invasive epithelial ovarian cancer cases were each matched to one to two controls on age, menopausal status, time since last menstrual period, current hormone use, and other relevant factors. FSH concentrations were classified into ranked thirds of low, medium, or high based on the distribution among controls. Conditional logistic regression was used to estimate the odds ratio (OR) across increasing thirds of FSH concentrations. Results of the analysis showed that ovarian cancer risk decreased with higher FSH concentrations (p-trend =0.005). Compared to the lowest third of FSH concentrations, the odds ratio among those in the middle and highest thirds were 0.45 (95% Confidence Interval (CI) 0.20– 1.00) and 0.26 (95% CI 0.10–0.70), respectively. Associations persisted after excluding cases diagnosed within five years of follow-up. In conclusion, a reduction in subsequent risk of invasive epithelial ovarian cancer was observed among women with higher circulating FSH concentrations. These findings contradict the hypothesized role of FSH as a risk factor in ovarian carcinogenesis.
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影响因子：
120.7
作者：
HELZLSOUER, KJ;BUSH, TL;COMSTOCK, GW
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