Tinnitus and auditory cortex; Using adapted functional near-infrared-spectroscopy to expand brain imaging in humans.
Tinnitus and auditory cortex; Using adapted functional near-infrared-spectroscopy to expand brain imaging in humans.
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耳鸣与听觉皮层；使用适应的功能性近红外光谱来扩展人类的大脑成像。
DOI：
10.1002/lio2.510
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发表时间：
2021-03
影响因子：
1.9
通讯作者：
Basura GJ
中科院分区：
文献类型：
--
作者：
Zhai T;Ash-Rafzadeh A;Hu X;Kim J;San Juan JD;Filipiak C;Guo K;Islam MN;Kovelman I;Basura GJ
幻听感觉(耳鸣)可能是由于听觉皮质内大脑活动的改变引起的。在耳鸣动物模型中，听觉皮质神经元表现出自发放电率增加。这可能是耳鸣的一个核心特征。功能性近红外光谱(FNIRS)在人类听觉皮质中也显示了类似的发现。由于颅骨厚度的原因，目前使用帽状记录的fNIR方法仅限于信号穿透深度∼3 cm。为了解决这一局限性，我们提出了一种创新的fNIRS方法，通过适应于外耳道的探头。改装后的探头被放置在更深更靠近大脑颞叶的地方，以绕过限制头骨的区域，并改善神经记录。20名患有耳鸣的成年人和20名非耳鸣对照组在标准耳帽和适应的耳道fNIRS神经成像期间接受沉默和宽带噪声(BBN)。评估者没有失明，但两组的方案和后处理是相同的。耳鸣参与者的标准fNIRS测量显示，在静默期间，听觉皮质活动增加，而在BBN听觉刺激期间，这种活动受到抑制。相反，控制组在有噪音的情况下表现出更多的激活，但在安静的情况下没有。重要的是，改装的耳道fNIRS探头在耳鸣和对照组中表现出与CAP探头相似的血流动力学反应。在这项概念验证研究中，我们成功地制造、调整和利用了一种新的fNIRS技术，该技术复制了传统CAP fNIRS探针的既定发现。这一令人兴奋的新创新通过复制以前和当前在听觉皮质的CAP发现进行了验证，可能会应用于未来的研究，不仅研究耳鸣时的大脑变化，还研究可能涉及颞叶和周围脑区的其他病理状态的大脑变化。没有。
Phantom sound perception (tinnitus) may arise from altered brain activity within auditory cortex. Auditory cortex neurons in tinnitus animal models show increased spontaneous firing rates. This may be a core characteristic of tinnitus. Functional near‐infrared spectroscopy (fNIRS) has shown similar findings in human auditory cortex. Current fNIRS approaches with cap recordings are limited to ∼3 cm depth of signal penetration due to the skull thickness. To address this limitation, we present an innovative fNIRS approach via probes adapted to the external auditory canal. The adapted probes were placed deeper and closer to temporal lobe of the brain to bypass confining skull bone and improve neural recordings. Twenty adults with tinnitus and 20 nontinnitus controls listened to periods of silence and broadband noise (BBN) during standard cap and adapted ear canal fNIRS neuroimaging. The evaluators were not blinded, but the protocol and postprocessing for the two groups were identical. Standard fNIRS measurements in participants with tinnitus revealed increased auditory cortex activity during silence that was suppressed during auditory stimulation with BBN. Conversely, controls displayed increased activation with noise but not during silence. Importantly, adapted ear canal fNIRs probes showed similar hemodynamic responses seen with cap probes in both tinnitus and controls. In this proof of concept study, we have successfully fabricated, adapted, and utilized a novel fNIRS technology that replicates established findings from traditional cap fNIRS probes. This exciting new innovation, validated by replicating previous and current cap findings in auditory cortex, may have applications to future studies to investigate brain changes not only in tinnitus but in other pathologic states that may involve the temporal lobe and surrounding brain regions. NA.
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影响因子：
1.8
作者：
Dehmel, S.;Cui, Y. L.;Shore, S. E.
通讯作者：
Shore, S. E.
DOI：
10.1044/2015_jslhr-l-14-0278
发表时间：
2016-04-01
影响因子：
2.6
作者：
Bisconti, Silvia;Shulkin, Masha;Kovelman, Ioulia
通讯作者：
Kovelman, Ioulia
影响因子：
5.7
作者：
Huppert, TJ;Hoge, RD;Boas, DA
通讯作者：
Boas, DA
影响因子：
2.5
作者：
Basura, Gregory J.;Koehler, Seth D.;Shore, Susan E.
通讯作者：
Shore, Susan E.
影响因子：
2.8
作者：
Takacs, Joseph D.;Forrest, Taylor J.;Basura, Gregory J.
通讯作者：
Basura, Gregory J.