Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics.
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics.
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DOI：
10.1038/s41467-018-04965-4
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发表时间：
2018-07-03
影响因子：
16.6
通讯作者：
Price RN
中科院分区：
文献类型：
--
作者：
Auburn S;Benavente ED;Miotto O;Pearson RD;Amato R;Grigg MJ;Barber BE;William T;Handayuni I;Marfurt J;Trimarsanto H;Noviyanti R;Sriprawat K;Nosten F;Campino S;Clark TG;Anstey NM;Kwiatkowski DP;Price RN
尽管有证据表明存在高度氯喹耐药性，但马来西亚间日疟原虫感染的发病率在过去十年中显著下降。在这里，我们调查了来自马来西亚沙巴的51个分离株中接近消除的间日疟原虫种群的遗传变化，并将这些与来自泰国的104个分离株和来自印度尼西亚的104个分离株的数据进行了比较。沙巴显示出广泛的人口结构，反映了以前在柬埔寨出现的青蒿素耐药恶性疟原虫创始人人口。54%的沙巴分离株具有相同的基因组，与快速克隆扩增一致。在整个沙巴，已知与抗疟药物耐药性相关的位点的患病率很高。这三个国家之间的差异的措施揭示了几个基因区域下假定的选择在沙巴。我们的研究结果强调了与寄生虫复活有关的重要因素和分子线索，可用于监测间日疟原虫消除结束阶段的低流行人群。尽管有证据表明存在氯喹耐药性，但马来西亚的间日疟原虫发病率在过去十年中显著下降。在这里，奥本等人比较了马来西亚间日疟原虫的种群结构与中度和高度传播的地区，并确定了假定选择下的遗传区域。
The incidence of Plasmodium vivax infection has declined markedly in Malaysia over the past decade despite evidence of high-grade chloroquine resistance. Here we investigate the genetic changes in a P. vivax population approaching elimination in 51 isolates from Sabah, Malaysia and compare these with data from 104 isolates from Thailand and 104 isolates from Indonesia. Sabah displays extensive population structure, mirroring that previously seen with the emergence of artemisinin-resistant P. falciparum founder populations in Cambodia. Fifty-four percent of the Sabah isolates have identical genomes, consistent with a rapid clonal expansion. Across Sabah, there is a high prevalence of loci known to be associated with antimalarial drug resistance. Measures of differentiation between the three countries reveal several gene regions under putative selection in Sabah. Our findings highlight important factors pertinent to parasite resurgence and molecular cues that can be used to monitor low-endemic populations at the end stages of P. vivax elimination. Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selection.
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影响因子：
3.7
作者：
Abdullah NR;Barber BE;William T;Norahmad NA;Satsu UR;Muniandy PK;Ismail Z;Grigg MJ;Jelip J;Piera K;von Seidlein L;Yeo TW;Anstey NM;Price RN;Auburn S
通讯作者：
Auburn S
影响因子：
3.8
作者：
Hostetler JB;Lo E;Kanjee U;Amaratunga C;Suon S;Sreng S;Mao S;Yewhalaw D;Mascarenhas A;Kwiatkowski DP;Ferreira MU;Rathod PK;Yan G;Fairhurst RM;Duraisingh MT;Rayner JC
通讯作者：
Rayner JC
与柬埔寨恶性疟原虫疟疾双氢青蒿素-哌喹失败相关的遗传标记：基因型-表型关联研究。
DOI：
10.1016/s1473-3099(16)30409-1
发表时间：
2017-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Amato R;Lim P;Miotto O;Amaratunga C;Dek D;Pearson RD;Almagro-Garcia J;Neal AT;Sreng S;Suon S;Drury E;Jyothi D;Stalker J;Kwiatkowski DP;Fairhurst RM
通讯作者：
Fairhurst RM
影响因子：
3.7
作者：
Diez Benavente E;Ward Z;Chan W;Mohareb FR;Sutherland CJ;Roper C;Campino S;Clark TG
通讯作者：
Clark TG
影响因子：
3.3
作者：
Devine, Angela;Kenangalem, Enny;Yeung, Shunmay
通讯作者：
Yeung, Shunmay