Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
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mu1-阿片受体可能参与芬太尼或吗啡诱导的脊髓上和脊柱部位的镇痛作用。
DOI：
10.1016/s0024-3205(01)01550-8
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发表时间：
2002
期刊：
影响因子：
6.1
通讯作者：
Tsutomu Suzuki
中科院分区：
文献类型：
--
作者：
M. Narita;S. Imai;Yumiko Itou;Y. Yajima;Tsutomu Suzuki
Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and physical dependence in the clinical setting. The present study was designed to investigate the mechanisms of fentanyl- or morphine-induced antinociception at both supraspinal and spinal sites. In the mouse tail-flick test, the antinociceptive effects induced by both fentanyl and morphine were blocked by either the μ1-opioid receptor antagonist naloxonazine or the μ1/μ2-opioid receptor antagonist β-funaltrexamine (β-FNA) after s.c., i.c.v. or i.t. injection. In contrast, both fentanyl and morphine given i.c.v. or i.t. failed to produce antinociception in μ1-deficient CXBK mice. These findings indicate that like morphine, the antinociception induced by fentanyl may be mediated predominantly through μ1-opioid receptors at both supraspinal and spinal sites in mice. We also determined the ED50values for s.c.-, i.c.v.- and i.t.-administered fentanyl- or morphine-induced antinociception in mice. The ED50values for s.c.-, i.c.v.- and i.t.-administered fentanyl-induced antinociception were 73.7, 18.5 and 1.2-fold lower than that of morphine, respectively. The present data clearly suggest the usefulness of peripheral treatment with fentanyl for the control of pain.
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影响因子：
3.6
作者：
K. Raynor;Hayeoung Kong;Yan Chen;K. Yasuda;Lei Yu;G. Bell;T. Reisine
通讯作者：
K. Raynor;Hayeoung Kong;Yan Chen;K. Yasuda;Lei Yu;G. Bell;T. Reisine
纳洛嗪和β-富纳曲明对 mu 1 和 mu 2 阿片类药物作用的拮抗作用的比较。
影响因子：
6.1
作者：
Pick,CG;Paul,D;Pasternak,GW
通讯作者：
Pasternak,GW
使用计算机放射自显影减影技术对大鼠大脑中 mu1 阿片受体进行可视化。
DOI：
10.1073/pnas.82.19.6667
发表时间：
1985
影响因子：
11.1
作者：
Goodman,RR;Pasternak,GW
通讯作者：
Pasternak,GW
两种药理学不同的脊髓上 mu 镇痛系统在遗传不同的小鼠品系中的独立表达。
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Pick,CG;Nejat,RJ;Pasternak,GW
通讯作者：
Pasternak,GW
大鼠连续输注吗啡、哌替啶或芬太尼后对 mu 激动剂镇痛活性产生耐受。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Paronis,CA;Holtzman,SG
通讯作者：
Holtzman,SG