Exosomes: an overview of biogenesis, composition and role in ovarian cancer.
Exosomes: an overview of biogenesis, composition and role in ovarian cancer.
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DOI：
10.1186/1757-2215-7-14
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发表时间：
2014-01-25
影响因子：
4
通讯作者：
Kakar SS
中科院分区：
文献类型：
--
作者：
Beach A;Zhang HG;Ratajczak MZ;Kakar SS
外泌体是微小的膜结合囊泡，其在正常和病理状态期间由大多数增殖细胞类型过度产生。它们的水平在怀孕和癌症等疾病状态期间上调。外泌体含有多种蛋白质、脂质、RNA、非转录RNA、微小RNA和小RNA，其代表它们的细胞来源并从供体细胞穿梭至受体细胞。从细胞间通讯到肿瘤增殖，外泌体发挥着各种各样的功能，既有帮助，也有有害。作为生物标志物，外泌体可适用于诊断评估以及无细胞抗肿瘤疫苗。卵巢癌的外泌体与正常无癌个体的外泌体相比含有不同的蛋白质和miRNA组。这些分子可用作多个“条形码”，用于开发卵巢癌早期检测的诊断工具。
Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such as cancer. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, microRNAs and small RNAs that are representative to their cellular origin and shuttle from a donor cell to a recipient cell. From intercellular communication to tumor proliferation, exosomes carry out a diverse range of functions, both helpful and harmful. Useful as biomarkers, exosomes may be applicable in diagnostic assessments as well as cell-free anti-tumor vaccines. Exosomes of ovarian cancer contain different set of proteins and miRNAs compared to exosomes of normal, cancer-free individuals. These molecules may be used as multiple “barcode” for the development of a diagnostic tool for early detection of ovarian cancer.
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DOI：
10.1073/pnas.1304718110
发表时间：
2013-07-16
影响因子：
11.1
作者：
Delorme-Axford, Elizabeth;Donker, Rogier B.;Coyne, Carolyn B.
通讯作者：
Coyne, Carolyn B.
影响因子：
6.4
作者：
Janowska-Wieczorek, A;Wysoczynski, M;Ratajczak, MZ
通讯作者：
Ratajczak, MZ
DOI：
10.1083/jcb.97.2.329
发表时间：
1983-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Harding C;Heuser J;Stahl P
通讯作者：
Stahl P
影响因子：
8.8
作者：
Bryant, R. J.;Pawlowski, T.;Catto, J. W. F.;Marsden, G.;Vessella, R. L.;Rhees, B.;Kuslich, C.;Visakorpi, T.;Hamdy, F. C.
通讯作者：
Hamdy, F. C.
影响因子：
3.7
作者：
Gallo A;Tandon M;Alevizos I;Illei GG
通讯作者：
Illei GG