MicroRNA-21 expression is associated with overall survival in patients with glioma.
MicroRNA-21 expression is associated with overall survival in patients with glioma.
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DOI：
10.1186/1746-1596-8-200
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发表时间：
2013-12-10
影响因子：
2.6
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Wu L;Li G;Feng D;Qin H;Gong L;Zhang J;Zhang Z
MicroRNA-21已被证实与胶质瘤的增殖和侵袭相关;因此，我们试图阐明miR-21在WHO I至IV级胶质瘤组织中表达的临床价值。使用实时PCR评价了152对人脑胶质瘤和非肿瘤性脑组织。同时分析miR-21表达与胶质瘤患者临床病理因素及预后的关系。在本研究中，使用Kaplan-Meier方法和考克斯比例风险模型进行生存分析。miR-21在胶质瘤组织中的表达显著高于相应的非肿瘤脑组织（P < 0.001）。这种观察到的高miR-21表达与胶质瘤患者的高病理分级和Karnofsky表现评分显著相关。此外，低miR-21表达患者的总体生存期显著长于高miR-21表达患者（P < 0.001）。多因素考克斯回归分析显示miR-21可能是胶质瘤患者生存的独立预后指标。我们的数据表明，miR-21可能是胶质瘤，特别是那些高病理分级的胶质瘤的候选独立标志物，这也可能是一个潜在的治疗靶点的分子胶质瘤治疗。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1445749171109834。
MicroRNA-21 has been proved to be associated with glioma proliferation and invasion; thus, we sought to clarify the clinical value of miR-21 expression in glioma tissues with WHO grade I to IV. One hundred and fifty-two pairs of human gliomas and non-neoplastic brain tissues were evaluated using real-time PCR. The association of miR-21 expression with clinicopathological factors or the prognosis of glioma patients was also analyzed. In this study, survival analysis was performed using the Kaplan-Meier method and Cox’s proportional hazards model. MiR-21 was more greatly expressed in glioma tissues compared to the corresponding non-neoplastic brain tissues (P < 0.001). This observed high miR-21 expression was significantly associated with high pathological grades and the Karnofsky performance score of glioma patients. In addition, overall patient survival for those with low miR-21 expression was significantly longer than those patients with high miR-21 expression (P < 0.001). Moreover, multivariate Cox regression analysis indicated that miR-21 might be an independent prognostic marker for glioma patient survival. Our data show that miR-21 may be a candidate independent marker for gliomas, especially those with high pathological grades, and this could also be a potential therapeutic target for molecular glioma therapy. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1445749171109834.
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miRNA-21过表达促进非小细胞肺癌的放射抗性
DOI：
10.1186/1748-717x-8-146
发表时间：
2013-06-19
期刊：
Radiation oncology (London, England)
影响因子：
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作者：
Wang XC;Wang W;Zhang ZB;Zhao J;Tan XG;Luo JC
通讯作者：
Luo JC
影响因子：
3.7
作者：
Sanchez-Diaz PC;Hsiao TH;Chang JC;Yue D;Tan MC;Chen HI;Tomlinson GE;Huang Y;Chen Y;Hung JY
通讯作者：
Hung JY
影响因子：
5
作者：
Zhang, Ji-guang;Wang, Jian-jun;Yang, Guang-hai
通讯作者：
Yang, Guang-hai
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影响因子：
2.8
作者：
Zhang, Hai-Liang;Yang, Li-Feng;Ye, Ding-Wei
通讯作者：
Ye, Ding-Wei
影响因子：
4.8
作者：
Yang, Chuan He;Yue, Junming;Pfeffer, Lawrence M.
通讯作者：
Pfeffer, Lawrence M.